5.38763
CD38 Inhibitor
≥98% (HPLC), solid, CD38 inhibitor, Calbiochem®
別名:
CD38 Inhibitor, Compound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
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この商品について
実験式（ヒル表記法）:
C22H27N3O3S
CAS番号:
分子量:
413.53
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
製品名
CD38 Inhibitor,
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light brown to brown, white to light brown
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
SMILES string
[s]1cncc1c2cc3c(cc2)N(C(=O)C=C3N[C@@H]4CC[C@H](CC4)OCCOC)C
InChI
1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChI key
VJQALSOBHVEJQM-QAQDUYKDSA-N
General description
A cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CD38
CD38
Reversible: yes
Target IC50: 7.3 & 1.9 nM for human & mouse CD38, respectively
Packaging
Packaged under inert gas
Other Notes
Haffner, C.D., et al. 2015. J. Med. Chem.58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab.27, 1081.
Tarrago, M.G., et al. 2018 Cell. Metab.27, 1081.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。