566313
SIRT1 Activator II
The SIRT1 Activator II, also referenced under CAS 374922-43-7, modulates the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Biochemicals applications.
別名:
SIRT1 Activator II, 3-(Benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[4,5-b]quinoxalin-2-amine , SIRT1 Activator II, CAY10602
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この商品について
実験式（ヒル表記法）:
C22H15FN4O2S
CAS番号:
分子量:
418.44
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
FC(C=C1)=CC=C1N2C(N)=C(S(C3=CC=CC=C3)(=O)=O)C4=C2N=C5C(C=CC=C5)=N4
InChI
1S/C22H15FN4O2S/c23-14-10-12-15(13-11-14)27-21(24)20(30(28,29)16-6-2-1-3-7-16)19-22(27)26-18-9-5-4-8-17(18)25-19/h1-13H,24H2
InChI key
CSFVFDHRYKBBPD-UHFFFAOYSA-N
General description
A cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10 µM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-α release in THP-1 cells by ~10-fold more potent than resveratrol (Cat. No. 554325).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lavu, S., et al. 2008. Nat. Rev. Drug Discov.7, 841.
Nayagam, V.M., et al. 2006. J. Biomol. Screen.11, 959.
Nayagam, V.M., et al. 2006. J. Biomol. Screen.11, 959.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable