567737
S1P4 Receptor Antagonist, CYM50358
The S1P4 Receptor Antagonist, CYM50358 controls the biological activity of S1P4 Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.
別名:
S1P4 Receptor Antagonist, CYM50358, CYM50358
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この商品について
実験式（ヒル表記法）:
C20H18Cl2N2O2
CAS番号:
分子量:
389.28
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
PubChem Substance ID:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL, clear, colorless
shipped in
ambient
storage temp.
2-8°C
SMILES string
CC1=CC(=CC(=C1NC(=O)C2=CC=C(O2)C3=C(C=CC(=C3)Cl)Cl)C)CN
InChI
1S/C20H18Cl2N2O2/c1-11-7-13(10-23)8-12(2)19(11)24-20(25)18-6-5-17(26-18)15-9-14(21)3-4-16(15)22/h3-9H,10,23H2,1-2H3,(H,24,25)
InChI key
QWJOPXDAQCDRRM-UHFFFAOYSA-N
General description
An arylcarboxamide that acts as a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) antagonist (IC50 = 25 nM), among a panel of five S1P receptors. It is shown to inhibit other S1P isoforms only at much higher concentrations (IC50 = 6.4 µM, 3.9 µM, 5.5 µM, and 25 µM for S1P1, S1P2, S1P5, and S1P3 (95% inhibition), respectively).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Guerrero, M., et al. 2011. Bioorg. Med. Chem. Lett.21, 3632.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
保管分類
11 - Combustible Solids
wgk
WGK 3