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572630

SU-5402

Name: SU-5402
Brand: MM

≥95% (HPLC), lyophilized solid, FGFR1 inhibitor, Calbiochem

別名:

SU5402, 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone

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この商品について

実験式（ヒル表記法）:

C₁₇H₁₆N₂O₃

CAS番号:

215543-92-3

分子量:

296.32

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD08235144

Assay:

≥95% (HPLC)

Form:

lyophilized solid

Quality level:

200

Storage condition:

OK to freeze, protect from light

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特性

製品名

SU5402, SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP).

Quality Level

200

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[nH]1c(c(c(c1)C)CCC(=O)O)\C=C2\c3c(cccc3)NC\2=O

InChI

1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-

InChI key

JNDVEAXZWJIOKB-JYRVWZFOSA-N

詳細

General description

A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC₅₀ = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC₅₀ = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Fibroblast growth factor receptor 1 (FGFR1)

Product competes with ATP.

Reversible: yes

Target IC₅₀: 10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Mohammadi, M., et al. 1997. Science 276, 955.

Legal Information

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

572630-1MG: + 572630-2MG: + 572630-500UG: + 572630-50MG: + 572630-MG: + 572630-100MG: + 572630-10MG: + 572630-25MG:

jan

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA）を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

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グローバルトレードアイテム番号

カタログ番号	GTIN
572630-2MGCN	04055977266238
572630-500UGCN	04055977266269
572630-1MGCN	04055977266207