580549
Tauroursodeoxycholic Acid, Sodium Salt
Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.
別名:
Tauroursodeoxycholic Acid, Sodium Salt, Sodium Tauroursodeoxycholate
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この商品について
実験式（ヒル表記法）:
C26H44NO6S · Na
CAS番号:
分子量:
521.69
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.21
description
RTECS - KI7372500
Quality Segment
assay
≥97% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 100 mg/mL
shipped in
ambient
storage temp.
15-25°C
SMILES string
[S](=O)(=O)(O)CCNC(=O)CC[C@H]([C@@H]1[C@@]2(C(C3[C@H](C[C@H]4[C@@](C3CC2)(CC[C@H](C4)O)C)O)CC1)C)C
InChI
1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,22+,24?,25+,26-/m1/s1
InChI key
BHTRKEVKTKCXOH-AYSJQVDDSA-N
General description
Detergent useful for the solubilization of lipids and membrane-bound proteins. Has cryoprotective effects against hydrophobic bile salts in rats. Also reported to inhibit pepsin activity in vitro.
Application
- Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats.: This study highlights the efficacy of tauroursodeoxycholic acid, sodium salt in reducing endoplasmic reticulum stress, suggesting its utility in preventing vascular complications in diabetes (Gaikwad AB et al., 2022).
Other Notes
Ozcan, U., et al. 2006. Science313, 1137.
Miyake, H., et al. 1999. Dig. Dis. Sci.44, 197.
Eto, T. and Tompkins, R.K. 1985. Am. J. Surg.150, 564.
Miyake, H., et al. 1999. Dig. Dis. Sci.44, 197.
Eto, T. and Tompkins, R.K. 1985. Am. J. Surg.150, 564.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable