582231
Tetanus Toxoid
from Clostridium tetani, , lyophilized, nontoxic antigenic agent, Calbiochem®
別名:
TTx
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この商品について
UNSPSC Code:
12352200
NACRES:
NA.77
Form:
lyophilized
Storage condition:
OK to freeze
製品名
Tetanus Toxoid, Clostridium tetani, This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
Quality Segment
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
soluble (Reconstitute in 50 µl of sterile distilled H2O)
shipped in
ambient
storage temp.
2-8°C
General description
Tetanus Toxoid belongs to the vaccine class of medications. Useful for immunization against tetanus and wound prophylaxis. Non-toxic as determined by an LD50 assay in mice.
Application
Tetanus Toxoid, Clostridium tetani has been used: as a positive-control antigen used to assess antibodies against different SARS-CoV-2 proteins and peptides in patients; to assess lymphocyte proliferation in rabbit PBMC cultures in response to recall antigen stimulation; a stimulus for PBMCs from chronic HBV carrier donors in a T cell proliferation assay
Biochem/physiol Actions
Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.
Features and Benefits
- Prepared by formaldehyde inactivation of tetanus toxin.
- Prepared by formaldehyde inactivation of tetanus toxin.
- Toxoid retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
- Cell permeable: no
- Product does not compete with ATP.
- Reversible: no
Physical form
Lyophilized from 100 mM histidine, 100 mM NaCl, 5% trehalose, pH 7.0.
Preparation Note
Reconstitute in 50 µl of sterile distilled H₂O
Other Notes
Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
582231-25UG: + 582231-100UG: + 582231-0UG: + 582231-UG:
jan
試験成績書（COA）
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