Thrombospondin, Human Platelets

Native thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by α-thrombin. An angiogenesis inhibitor that blocks the FGF-induced neovascularization of the rat cornea. An inducer of platelet aggregation. Synthesized by a number of different cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.

Lyophilized from 600 mM NaCl, 20 mM Tris, 1 mM CaCl₂, 20% sucrose, pH 7.8.

Following reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 1 week at 4°C or for at least 1 month at -70°C. Product is extremely adherent to surfaces; keep frozen (-70°C) before use and use siliconized surfaces to insure product recovery.

Please refer to lot-specific reconstitution volume on the vial label.

Prepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

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Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA87, 6624.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)