Anti-Sox2, Alexa Fluor^™ 488 Conjugate Antibody

SOX2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.

The unconjugated antibody (AB5603) tested on western blot detects Sox2 in whole cell or nuclear extracts as a protein band at 34 kDa

Synthetic peptide from human Sox2.

Detect Sox2 using this Anti-Sox2, Alexa Fluor 488 Conjugate Antibody validated for use in ICC.

Research Category
Neuroscience

Research Sub Category
Transcription Factors

Affinity purified

Purified rabbit polyclonal conjugated to Alexa Fluor^™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Control
Undifferentiated ReNcell VM neural progenitor cells

Evaluated by Immunocytochemistry in undifferentiated ReNcell VM neural progenitor cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Sox2 in undifferentiated ReNcell VM neural progenitor cells.

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