Anti-DHODH Antibody

Dihydroorotate oxidase (DHODH) is also called Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase). DHODH is a member the dihydroorotate dehydrogenase (Type 2) family and is involved in pyrimidine biosynthesis. DHODH catalyzes the conversion of dihydroorotate to orotate using quinone as an electron acceptor. DHODH defects can cause postaxial acrofacial dysostosis (POADS).

~43 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

Epitope: Topological Domain ( Mitochondrial intermembrane)

KLH-conjugated linear peptide corresponding to the Topological Domain (Mitochondrial intermembrane) of human DHODH.

Anti-DHODH Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected DHODH in human testis and breast carcinoma sections.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Other Homologies: Rat (93% sequence homology) and Mouse (86% sequence homology).

This antibody recognizes the Topological Domain (Mitochondrial intermembrane) of DHODH.

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
T47D cell lysate

Evaluated by Western Blotting in T47D cell lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected DHODH in 10 µg of T47D cell lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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