ABE572
Anti-N6-methyladenosine (m6A) Antibody
from rabbit
別名:
m6A
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この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Technique(s):
ChIP: suitable, RIP: suitable, dot blot: suitable
Application:
ChIP, DB, RIP
Citations:
91
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity (predicted by homology)
all
technique(s)
ChIP: suitable, RIP: suitable, dot blot: suitable
shipped in
wet ice
target post-translational modification
unmodified
General description
N6-methyladenosine (m6A), or methylation of the N6 position of adenosine is a posttranscriptional modification of RNA. Due to a lack of analytical methods, N6-methyladenosine is poorly understood, but new evidence suggests that it is a very common base modification and important physiological regulator. N6-methyladenosine is markedly increased throughout brain development, and is enriched near stop codons, microRNA-binding sites and UTRs, which indicates a fundamental role in the regulation of gene expression. N6-methyladenosine is also highly conserved between human and mouse.
Immunogen
BSA-conjugated N6-methyladenosine.
Application
Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in RNA containing N6-methyladenosine (Dominissini, D., et al. (2012). Nature. 485(7397):201-206.; Meyer, K. D., et al. (2012). Cell. 149(7):1635-1646.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012). Cell. 149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012). Cell. 149(7):1635-1646.; Jia, G., et al. (2011). Nat Chem Biol. 7(12):885-887.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012). Cell. 149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012). Cell. 149(7):1635-1646.; Jia, G., et al. (2011). Nat Chem Biol. 7(12):885-887.).
Detect N6-methyladenosine (m6A) using Anti-N6-methyladenosine (m6A) Antibody validated for use in Dot Blot, Chromatin IP (ChIP) & RNA Binding Protein IP (RIP).
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Chromatin Biology
Physical form
Format: Purified
Protein A purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Dot Blot in oligomers containing N6-methyladenosine.
Dot Blot Analysis: 1 µg/mL of this antibody detected N6-methyladenosine in oligomers containing N6-methyladenosine.
Dot Blot Analysis: 1 µg/mL of this antibody detected N6-methyladenosine in oligomers containing N6-methyladenosine.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
ABE572:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Andrea Orioli et al.
Genome research, 26(5), 624-635 (2016-03-05)
RNA polymerase III (Pol III) is tightly controlled in response to environmental cues, yet a genomic-scale picture of Pol III regulation and the role played by its repressor MAF1 is lacking. Here, we describe genome-wide studies in human fibroblasts that
Xiaoling Liu et al.
Analytical chemistry, 90(9), 5546-5551 (2018-04-14)
N6-methyladenine (6mA) is a rediscovered DNA modification in eukaryotic genomes. To explore the distribution and functions of 6mA, it is of paramount option to use immunoprecipitation to select 6mA-containing DNA fragments for genome-wide sequencing. Presumably, most of the 6mA-free fragments
Hua Su et al.
BMC genomics, 21(1), 39-39 (2020-01-15)
Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m6A-modified. The abundance of circRNAs was influenced by m6A. Furthermore, the significance of m6A
Taylor M Nye et al.
PLoS pathogens, 15(6), e1007841-e1007841 (2019-06-18)
DNA methylation is pervasive across all domains of life. In bacteria, the presence of N6-methyladenosine (m6A) has been detected among diverse species, yet the contribution of m6A to the regulation of gene expression is unclear in many organisms. Here we
Jérôme Lannes et al.
Scientific reports, 6, 31563-31563 (2016-08-20)
The GnRH neurohormone is the main activator of the pituitary gonadotropins, LH and FSH. Here we investigated the contribution of microRNAs in mediating GnRH activation. We first established that miR-125b targets several actors of Gαq/11 signalling pathway, without altering Gαs
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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