GR11L
Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)
lyophilized, clone αIR3, Calbiochem®
別名:
Anti-IGF-IR, Anti-Insulin-Like Growth Factor Receptor, Anti-Insulin-Like Growth Factor Receptor, Anti-IGF-IR
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この商品について
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
αIR3, monoclonal
Species reactivity:
human
Application:
—
Citations:
11
biological source
mouse
Quality Segment
antibody form
purified antibody
antibody product type
primary antibodies
clone
αIR3, monoclonal
form
lyophilized
does not contain
preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
dilution
(Immunofluorescence (1-5 µg/mL)
Immunoprecipitation (1 µg/sample)
Neutralization Studies (1 µg/mL;
Paraffin Sections (not recommended)
Immunoblotting (not recommended))
isotype
IgG1
shipped in
ambient
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... IGF1R(3480)
General description
This Anti-IGF-IR (Ab-1) Mouse mAb (αIR3) is validated for use in IF, IP, Neutralization Studies, Paraffin Sections, Immunoblotting for the detection of IGF-IR (Ab-1).
Immunogen
Human
Application
Immunofluorescence (1-5 µg/ml)
Immunoprecipitation (1 µg/sample)
Neutralization Studies (1 µg/ml; see application references)
Paraffin Sections (not recommended)
Immunoblotting (not recommended)
Immunoprecipitation (1 µg/sample)
Neutralization Studies (1 µg/ml; see application references)
Paraffin Sections (not recommended)
Immunoblotting (not recommended)
Physical form
Lyophilized from 20 mM ammonium bicarbonate solution, 100 µg BSA .
Preparation Note
Reconstitute with sterile phosphate buffered saline (PBS), pH 7.4, or sterile 20 mM Tris-saline (20 mM Tris containing 0.15 M NaCl), pH 7.4, to a final concentration of 100 µg/ml. Lyophilized antibodies should be resuspended at 4°C with occasional gentle mixing for at least two h. Following reconstitution, aliquot and freeze (-20°C) or refrigerate (4°C) with 0.1% sodium azide. Freezing of aliquots is recommended for long term storage of reconstituted product. Avoid freeze/thaw cycles of solutions.
Other Notes
Blocks IGF-I binding to the IGF-I receptor. May also weakly cross-react with the insulin receptor (see application references). It also inhibits the growth of MCF-7 cells in culture suggesting the IGF-I receptor may be involved in autocrine regulation of cell growth (see application references). Antibody should be titrated for optimal results in individual systems.
Roth, R. 1988. Science239, 1269.
Rohlik, Q.T., et al. 1987. Biochem. Biophy Res. Comm.149, 276.
Rosen, O.M. 1987. Science257, 1452.
Rechler, M.M., and Nissley, S.P. 1986. Hormone Res.24, 152.
Ullrich, A., et al. 1986. EMBO J.5, 2503.
Zapf, S., and Froesch, E.R. 1986. Hormone Res.24, 121.
Humbel, R.E. 1984. I. Chemistry in Li Hormonal proteins and peptides. Vol 12, Chap. 4 (Academic Press, New York, 1984).
Kull, F.C., et al.1983. J. Biol. Chem.258, 6561.
Rohlik, Q.T., et al. 1987. Biochem. Biophy Res. Comm.149, 276.
Rosen, O.M. 1987. Science257, 1452.
Rechler, M.M., and Nissley, S.P. 1986. Hormone Res.24, 152.
Ullrich, A., et al. 1986. EMBO J.5, 2503.
Zapf, S., and Froesch, E.R. 1986. Hormone Res.24, 121.
Humbel, R.E. 1984. I. Chemistry in Li Hormonal proteins and peptides. Vol 12, Chap. 4 (Academic Press, New York, 1984).
Kull, F.C., et al.1983. J. Biol. Chem.258, 6561.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
GR11L-100UG: + GR11L-MG:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。