MAB2168
Anti-Huntingtin Disease (HD/HTT) Antibody
CHEMICON®, mouse monoclonal, HU-2E8
製品名
Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8, ascites fluid, clone HU-2E8, Chemicon®
biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
HU-2E8, monoclonal
species reactivity
monkey, human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTT(3064), SLC6A4(6532)
Application
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8 is an antibody against Huntingtin Protein for use in ELISA, WB, IC, IH(P).
ELISA: 1:500-1:5,000
Western blot: 1:500-1:5,000
Immunohistochemistry on frozen and microwave oven treated paraffin sections
(human tissue): 1:500-1:5,000
Immunocytochemistry on transfected cells: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Western blot: 1:500-1:5,000
Immunohistochemistry on frozen and microwave oven treated paraffin sections
(human tissue): 1:500-1:5,000
Immunocytochemistry on transfected cells: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Biochem/physiol Actions
Reacts with Huntingtin protein from human and monkey. Weak to no reactivity with mouse. Has not been tested on other species.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Epitope: a.a. 2146-2541
Human huntingtin fragment from aa 2146 to 2541 as a fusion protein.
Physical form
Ascites fluid. Liquid, does not contain any preservative.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects.
Ciammola, A; Sassone, J; Alberti, L; Meola, G; Mancinelli, E; Russo, MA; Squitieri, F; Silani, V
Cell Death and Differentiation null
Wei Li et al.
The Journal of biological chemistry, 281(23), 15916-15922 (2006-04-06)
Huntington disease is an inherited neurodegenerative disorder that is caused by expanded CAG trinucleotide repeats, resulting in a polyglutamine stretch of >37 on the N terminus of the protein huntingtin (htt). htt is a large (347 kDa), ubiquitously expressed protein.
Ellen Sapp et al.
The Journal of biological chemistry, 287(16), 13487-13499 (2012-03-01)
Huntington disease (HD) is caused by polyglutamine expansion in the N terminus of huntingtin (htt). Analysis of human postmortem brain lysates by SDS-PAGE and Western blot reveals htt as full-length and fragmented. Here we used Blue Native PAGE (BNP) and
Hiroki Takano et al.
BMC neuroscience, 3, 15-15 (2002-10-16)
Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown inherent function. Huntingtin is moderately conserved, with 10
Amber L Southwell et al.
Human molecular genetics, 26(6), 1115-1132 (2017-01-21)
Huntington disease (HD) is a neurodegenerative disease caused by a mutation in the huntingtin (HTT) gene. HTT is a large protein, interacts with many partners and is involved in many cellular pathways, which are perturbed in HD. Therapies targeting HTT
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| MAB2168 | 04053252399664 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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