A1086
N-アセチル-Asp-Glu-Val-Asp-7-アミド-4-メチルクマリン
≥97% (HPLC), Fluorogenic caspase 3 substrate, powder
別名:
Ac-DEVD-AMC
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この商品について
実験式（ヒル表記法）:
C30H37N5O13
CAS番号:
分子量:
675.64
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
製品名
N-アセチル-Asp-Glu-Val-Asp-7-アミド-4-メチルクマリン, ≥97% (HPLC), powder
assay
≥97% (HPLC)
form
powder
composition
Peptide content, ~65%
color
white
solubility
DMSO: 10 mM
storage temp.
−20°C
SMILES string
CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1
InChI
1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,26-/m0/s1
InChI key
ALZSTTDFHZHSCA-RNVDEAKXSA-N
Application
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin has been used as a substrate for caspase-3 assay in human colon cancer cell line and in bone marrow mesenchymal stem cells.
Biochem/physiol Actions
カスパ-ゼ 3の蛍光基質です。カスパ-ゼ3は、細胞がアポト-シス状態にさらされたとき速やかに活性化され、ポリ(ADP-リボ-ス)ポリメラ-ゼを切断するプロテア-ゼです。
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)