H2138
塩化ヘキサメトニウム
solid (hygroscopic)
別名:
N,N,N,N′,N′,N′-ヘキサメチル-1,6-ヘキサンジアミニウムジクロライド, N,N,N,N′,N′,N′-ヘキサメチルヘキサメチレンジアンモニウムジクロライド, ヘキサメトニウムジクロライド
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この商品について
化学式:
(CH3)3N(Cl)(CH2)6N(Cl)(CH3)3
CAS番号:
分子量:
273.29
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-465-1
Beilstein/REAXYS Number:
3714806
MDL number:
Form:
solid (hygroscopic)
form
solid (hygroscopic)
color
white
solubility
H2O: soluble, ethanol: soluble
SMILES string
[Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C
InChI
1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChI key
PYIHTIJNCRKDBV-UHFFFAOYSA-L
Gene Information
General description
Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.
Application
Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.
Biochem/physiol Actions
Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)