P3076
血小板由来成長因子-AA ヒト
PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
別名:
PDGF−AA
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この商品について
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
28.5 kDa (containing 250 amino acid residues)
Impurities:
<1 EU/μg
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
≤1.0-3.0 ng/mL ED50
quality
endotoxin tested
mol wt
28.5 kDa (containing 250 amino acid residues)
packaging
pkg of 10 μg, pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PDGFRA(5154)
General description
Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.
Biochem/physiol Actions
Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.
Physical form
滅菌濾過したバッファ-で調製した溶液の凍結乾燥品
Analysis Note
生物活性は、BALB/c 3T3細胞のthymidine取り込みに対する用量依存的な促進活性として測定されています。
Other Notes
ヒトPDGFのA鎖からなるホモ二量体
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保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable