Parteck®機能性添加剤
固形製剤の設計では、医薬品有効成分（API）、バイオアベイラビリティ向上、薬物放出動態、特定の剤形、包装、保存期間など、考慮すべき要素が多数あります。添加剤は製剤を支えており、加工性、安定性、性能などの最終製剤の性質に影響します。したがって、適切な機能と高い品質の賦形剤を検討することが重要です。
Parteck® 機能性添加剤は、これらの製剤設計上の課題に留意しながら設計され、標準的な賦形剤を超える付加機能を持っています。これらの添加剤は粒子が最適化されており、錠剤化プロセス、特定の薬物送達技術、または溶解性の向上に合わせた特異的な粒子特性を持ちます。したがって、弊社のParteck® 機能性添加剤では、製剤の開発・製造における卓越した性能が保証されます。厳格な品質管理のEmprove® プログラムならびに規制関連のサポートや文書に裏打ちされているParteck® 添加剤は、お客様の承認プロセスを加速させる役に立ちます。
Products
錠剤化におけるフレキシビリティー
- 低い打錠圧で高い錠剤硬度が得られるため、頑丈で迅速に崩壊する錠剤を実現
- 独自の粒子表面でAPIの高用量にも低用量にも対応
- 直打用、湿式・乾式造粒用、フィルムコーティング用、滑沢用、および迅速崩壊用に特化された添加剤
最適化された薬物送達
- 口腔内崩壊錠や徐放性経口製剤など、薬物放出動態を変化させるオプション
- 乾燥粉末吸入などさまざまな投与経路に特化された添加剤
溶解性の向上
- ホットメルト押出用の特殊な添加剤、錠剤の溶解速度向上、およびユニークな表面構造を持つシリカ薬物担体
- 最終製剤の有効性を高めるAPIの溶解性向上
関連製品資料
- Article: Tablet Manufacturing Technologies for Solid Drug Formulation
Learn about common tablet manufacturing technologies and the advantages and disadvantages of each.
- Article: Active Pharmaceutical Ingredient (API) Stability in Solid Dose Formulation
This article describes the use of excipients to help address API stability issues.
- Article: API Solubility and Dissolution Enhancement Via Formulation
Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.
- Article: Dry Granulation in Solid Oral Formulation: Advantages of Spray-Dried Mannitol in Roll Compaction
In recent years, mannitol has gained popularity as an excipient in solid dosage formulation due to its beneficial physicochemical properties.
- Article: Solid Formulation Development Using Melt-based 3D Printing Technologies
3D printing can overcome challenges during formulation development, with a focus on enhancing API bioavailability in solid dispersions. Find out how in this technical article.
- Article: Use of Mannitol as an Excipient for Solid Drug Formulation
This article describes the advantages of mannitol when used as an excipient in solid drug formulation.
- Article: Improving API Solubility Using Hot Melt Extrusion Formulation With Polyvinyl Alcohol
Find out how Hot Melt Extrusion with polyvinyl alcohol (PVA) is used to enhance API solubility.
- Download: Formulation Handbook
Formulating pharmaceutical dosage forms: In this formulation handbook, we have compiled information and formulation examples that can help you when developing your formulation.
- White Paper: API Stability in Solid Dose Formulation – Exploring the Myth of Inert Excipients
Stable active pharmaceutical ingredients (APIs) are critical for drug formulation due to their impact on patient safety, regulatory acceptance, drug shelf-life, wastage, and storage requirements. API instability can lead to reduced drug dosage, formation of toxic degradation products, and increased costs for storage, potentially harming patient safety and economic viability.
- White Paper: New Opportunities for Oral Sustained Release Formulations with Polyvinyl Alcohol
Achieving appropriate release kinetics for an active pharmaceutical ingredient (API) is crucial for therapeutic success. Consistent API dosing in sustained release formulations ensures that blood plasma levels remain within the therapeutic window, maintaining efficacy while avoiding toxic side effects.
- White Paper: Considerations for Dosing Accuracy in a New Carrier for Dry Powder Inhalation
Inhalation drug delivery offers rapid action and good bioavailability, but precise dosing is difficult due to small dosage amounts and diverse forms of APIs.
- White Paper: The Developability Classification System (DCS): Enabling an Optimized Approach for Formulation of Poorly Soluble Molecules
Adequate solubility in gastrointestinal fluids is essential for the effectiveness of orally administered solid dosage forms. Most absorption occurs in the small intestine, where the drug needs to dissolve sufficiently to enter the systemic circulation. If the drug is not soluble in these fluids, it cannot produce the intended physiological effect.
