Single-Use Mixers
Mobius® single-use mixers efficiently blend pharmaceutical ingredients and prepare process solutions like buffers and media. Unlike traditional stainless-steel mixers which require downtime for cleaning processes, Mobius® single-use mixers minimize it with uncompromised mix quality. Ranging from 10 to 3000 L, they are designed to meet the broadest range of requirements. For Antibody Drug Conjugate (ADC) manufacturing, the Mobius® ADC Reactor is specifically designed for the key bioconjugation step.
Key benefits and features
Fast and consistent mixing that preserves product integrity, delivering higher yield and reducing costs.
Single-use design minimizes cross-contamination and enables closed, safe operations.
Ultimus® film provides superior strength to protect against leaks, increasing durability while maintaining ease of handling, flexibility, and conformity.
Single-use mixing solutions
Mobius® MIX
The mixing solution of choice for gentle mixing applications such as protein and shear-sensitive product homogenization.
Mobius® Power MIX
The mixing solution of choice for hard-to-dissolve materials and buffer preparation.
Mobius® ADC Reactor
The mixing systems perfected for bioconjugation.
Control boxes
Mobius® mixers and Mobius® ADC Reactor can be monitored and controlled locally or remotely with the Ready to Connect control box. For Mobius® MIX and Power MIX, the smart control box with Common Control Platform® (CCP®) enables remote monitoring of critical process parameters and supplies advanced process control during mixing operations.
Single-use mixing bags
Single-use mixing bags are made either with Ultimus® or with PureFlex™ films. The PureFlex™ family of single-use process container films are high purity, medical grade and coextruded to provide strength, flexibility, excellent gas barrier performance, and inert contact. The Ultimus® Film was designed for your more challenging single-use bioprocessing liquid applications, increasing durability while maintaining the ease of handling, flexibility, and conformity that single-use bioprocessing demands.
Bioprocessing development expertise and support
We bring together bioprocessing expertise, manufacturing technologies, and global infrastructure to support your process development and manufacturing needs, including cell culture, media and buffer preparation, and bioconjugation optimization. Our MSAT and Investment Projects teams support end-to-end facility design and implementation.
Frequently asked questions
What is a single-use mixer and how does it work?
A single-use mixer consists of a rigid reusable tank that houses a disposable bag containing the product to be blended. Mixing is achieved with a disposable impeller inside the bag, driven by a motor.
What are the key benefits of using single-use mixers compared to traditional reusable systems?
There are many benefits that single-use mixers bring:
- Eliminates CIP/SIP (Cleaning In Place/Sanitization In Place) and reduces cleaning-validation effort.
- Lowers cross-contamination risk with disposable components.
- Enables faster changeovers and higher throughput.
- Provides consistent, validated performance and easier documentation.
- Improves capital efficiency and supply-chain flexibility.
What blending capabilities do single-use mixers offer?
Single-use mixers can handle both liquid–liquid and solid–liquid blending like powder dissolution. They support low-shear mixing to preserve sensitive product quality and can accommodate higher-viscosity liquids.
Why do I need a specific mixer for ADCs?
A dedicated mixer for Antibody-Drug Conjugates (ADCs) is important because ADCs are highly sensitive biologics. Key reasons:
- Gentle, low-shear mixing to prevent protein unfolding/aggregation and preserve antibody integrity.
- Compatible materials and seals to avoid leachables that could affect conjugates or toxicity.
- Strict aseptic/sterile and closed-system operation to minimize contamination and exposure.
- Precise temperature control during heating and cooling to maintain stability during processing.
- Cleaning, validation, and GMP compliance to prevent cross-contamination between batches.
Learn more in this Mobius® ADC Reactors, Perfected for Bioconjugation of Antibody Drug Conjugates dedicated page.
How can I track process parameters in a single-use mixer?
You can monitor in real time via in-line speed, temperature, weight, pH and conductivity sensors, or perform off-line checks using NovaSeptum® SURe Assemblies sampling solution.
Related videos
Mobius® Power MIX single-use mixing systems
Discover our range of Mobius® Power MIX mixing systems, designed to meet your toughest buffer and media challenges.
Related articles
- It is important to evaluate the compatibility of the single-use components of an equipment dedicated to conjugation such as the Mobius® ADC reactor.
- ADC production relies on conjugation to link the cytotoxic payload to the mAb. Explore the benefits of a single-use reactor for efficient conjugation.
Related documents
- Data sheet: Mobius® MIX
The mixing solution of choice for gentle mixing applications.
- Data sheet: Mobius® Power MIX
The mixing solution of choice for hard-to-dissolve materials and buffer preparation.
- Data sheet: Mobius® ADC Reactor
A scalable family of single-use mixers perfected for bioconjugation.
- Infographic: Single-use benefits for ADC manufacturing
The Mobius® ADC Reactor allows for flexible manufacturing that reduces risk and waste for maximum efficiency.
- White paper: Performance characteristics of the Mobius® ADC Reactor for conjugation
This white paper describes a series of studies using a model fluid to evaluate the mixing performance of Mobius® ADC Reactor for bioconjugation.
- Application note: Comparison between experimental data and computational fluid dynamics in mixing applications
Computational fluid dynamics (CFD) is a powerful simulation tool that leads to an improved understanding of the process flow and can be a complimentary or alternative solution to physical mixing trials. This study compares empirical data with CFD results.
- Technical brief: Mobius® MIX500 disposable mixing system characterization
This study provides characterization data for the performance of the Mobius® MIX500 system at different impeller speeds, operating volumes, and viscosities, as well as operations in a cold room environment.
- Application note: Mobius® Power MIX: Scalability in mixing
This document shows the scalability between sizes in the three main categories of mixing: liquid-liquid, sinking powders and floating powders.
- Application note: Compatibility of a Mobius® single-use solution for ADC processing
This study evaluates physical compatibility and extractables results of a proposed single-use solution for bioconjugation, purification and sterile filtration of ADCs.
- Application note: Mobius® single-use mixing solution characterizing liquid blend times versus viscosity
This technical study characterizes the liquid blend time for each Mobius® single-use mixing system at a range of volumes, RPM, and viscosities, using a pH shift technique.
- Spare parts list: Mobius® ADC Reactor
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
