681500
WHI-P180
A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.
동의어(들):
WHI-P180, 4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C16H15N3O3
CAS 번호:
Molecular Weight:
297.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
제품 이름
WHI-P180, A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.
SMILES string
N(c3cc(ccc3)O)c1ncnc2c1cc(c(c2)OC)OC
InChI
1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
InChI key
BNDYIYYKEIXHNK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
pale yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Product does not compete with ATP.
Reversible: no
Target IC50: 1 µM for Cdk2
Cell permeable: no
Primary Target
Cdk2
Cdk2
Disclaimer
Toxicity: Standard Handling (A)
General description
A potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
Other Notes
Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
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국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 681500-1MGCN | 04055977260687 |
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