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681500

WHI-P180

Name: WHI-P180
Brand: MM

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.

동의어(들):

WHI-P180, 4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₆H₁₅N₃O₃

CAS 번호:

211555-08-7

Molecular Weight:

297.31

MDL number:

MFCD02683970

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

기술 서비스

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속성

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N(c3cc(ccc3)O)c1ncnc2c1cc(c(c2)OC)OC

InChI

1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)

InChI key

BNDYIYYKEIXHNK-UHFFFAOYSA-N

설명

General description

A potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC₅₀ = 1 µM) by blocking the ATP site.

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC₅₀ = 1 µM) by blocking the ATP site.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cdk2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1 µM for Cdk2

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c