143049
Aldrithiol™-2
98%
동의어(들):
2,2′-Dithiodipyridine, 2,2′-Dipyridyl disulfide
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H8N2S2
CAS 번호:
Molecular Weight:
220.31
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
218-343-1
Beilstein/REAXYS Number:
154629
MDL number:
Assay:
98%
Form:
solid
Quality Level
assay
98%
form
solid
mp
56-58 °C (lit.)
solubility
methanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
functional group
disulfide
storage temp.
2-8°C
SMILES string
S(Sc1ccccn1)c2ccccn2
InChI
1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H
InChI key
HAXFWIACAGNFHA-UHFFFAOYSA-N
General description
Aldrithiol™-2 is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent.
Application
Thiol reagent. Employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.
Aldrithiol™-2 was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.
Legal Information
Aldrithiol is a trademark of Sigma-Aldrich Co. LLC
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tetrahedron Letters, 35, 1267-1267 (1994)
Analytical Sciences, 10, 17-17 (1994)
J L Rossio et al.
Journal of virology, 72(10), 7992-8001 (1998-09-12)
Whole inactivated viral particles have been successfully used as vaccines for some viruses, but procedures historically used for inactivation can denature virion proteins. Results have been inconsistent, with enhancement of disease rather than protection seen in some notable instances following