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Merck

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430471

Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 50,000-75,000

동의어(들):

Lactel® B6006-1, PLGA

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
[C3H4O2]x[C2H2O2]y
UNSPSC Code:
12162002
PubChem Substance ID:
24866924
NACRES:
NA.23
MDL number:
MFCD00131930
기술 서비스
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도움 문의

Quality Level

100

form

amorphous

feed ratio

lactide:glycolide 85:15

mol wt

Mw 50,000-75,000

degradation timeframe

<6 months

viscosity

0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)

transition temp

Tg 45-50 °C

solubility

ethyl acetate, chloroform, acetone and THF: soluble

storage temp.

2-8°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

InChI

1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)

InChI key

XBBVURRQGJPTHH-UHFFFAOYSA-N

General description

Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.

Application

PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone. Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
MKCW1330
MKCW9918
MKCW1331
MKCT1966
MKCH4706

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모든 기사 보기
Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone
Capan Y, et al.
Aaps Pharmscitech, 4(2), 147-156 (2003)
Fabrication of blended polycaprolactone/poly (lactic-co-glycolic acid)/?-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration
Shim JH, et al.
Tissue Engineering: Part A, 19(3-4), 317-328 null
Manjae Gil et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(6), 1800024-1800024 (2018-06-26)
Anisotropically compartmentalized microparticles have attracted increasing interest in areas ranging from sensing, drug delivery, and catalysis to microactuators. Herein, a facile method is reported for the preparation of helically decorated microbuilding blocks, using a modified electrohydrodynamic cojetting method. Bicompartmental microfibers
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