64046
2,3-Dimercapto-1-propanol
≥98% (iodometric)
동의어(들):
BAL, British anti-Lewisite, DMP, Dimercaprol, Dithioglycerol
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
HOCH2CH(SH)CH2SH
CAS 번호:
Molecular Weight:
124.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-433-7
Beilstein/REAXYS Number:
1732058
MDL number:
Assay:
≥98% (iodometric)
InChI key
WQABCVAJNWAXTE-UHFFFAOYSA-N
InChI
1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2
SMILES string
OCC(S)CS
assay
≥98% (iodometric)
refractive index
n20/D 1.572-1.574, n20/D 1.573 (lit.)
bp
120 °C/15 mmHg (lit.)
density
1.239 g/mL at 25 °C (lit.)
functional group
hydroxyl, thiol
storage temp.
2-8°C
Quality Level
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General description
Dimercapto-1-propanol acts as a chelating agent and forms stable complexes with certain heavy metals, including arsenic, mercury, and lead.
Application
2,3-Dimercapto-1-propanol has been used in synthesizing novel (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives, which are potent tyrosinase inhibitors. It can also be considered for developing new drugs against AIDS due to its ability to inhibit HIV-1 tat activity.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
S Kubota et al.
AIDS research and human retroviruses, 6(7), 919-927 (1990-07-01)
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional
Metal chelators and neurotoxicity: lead, mercury, and arsenic
Bjorklund G, et al.
Archives of Toxicology, 91(12), 3787-3797 (2017)
Raoul Herbrecht et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(5), 713-720 (2014-11-22)
Strict definition of invasive aspergillosis (IA) cases is required to allow precise conclusions about the efficacy of antifungal therapy. The Global Comparative Aspergillus Study (GCAS) compared voriconazole to amphotericin B (AmB) deoxycholate for the primary therapy of IA. Because predefined
Megan O'Reilly et al.
American journal of physiology. Lung cellular and molecular physiology, 307(12), L948-L958 (2014-10-12)
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23-24 wk of gestation, the challenge of promoting lung growth
R Vos et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(12), 2736-2748 (2014-11-15)
Lymphocytic airway inflammation is a major risk factor for chronic lung allograft dysfunction, for which there is no established treatment. We investigated whether azithromycin could control lymphocytic airway inflammation and improve allograft function. Fifteen lung transplant recipients demonstrating acute allograft
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