739944
Resomer® RG 504, Poly(D,L-lactide-co-glycolide)
lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000
동의어(들):
PLGA
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS 번호:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
Quality Level
form
amorphous
feed ratio
lactide:glycolide 50:50
mol wt
Mw 38,000-54,000
degradation timeframe
<3 months
viscosity
0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
transition temp
Tg 46-50 °C
storage temp.
2-8°C
SMILES string
O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
InChI
1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
InChI key
LCSKNASZPVZHEG-UHFFFAOYSA-N
Application
Resomer® RG 504, Poly(ᴅ,ʟ-lactide-co-glycolide) can be used to prepare polymeric nanoparticles that are effective carriers for anti-cancer natural substances.
Poly(D, L-lactide-co-glycolide)microspheres can be used to fabricate a hemostatic delivery device forthrombin.
Poly(D, L-lactide-co-glycolide)microspheres can be used to fabricate a hemostatic delivery device forthrombin.
Features and Benefits
Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
Legal Information
Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
문서
In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.
Ananthakrishnan Soundaram Jeevarathinam et al.
Angewandte Chemie (International ed. in English) (2019-12-17)
We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging