H8378
D-α-Hydroxyglutaric acid disodium salt
≥95% (GC), cell analysisfor peptide synthesis
동의어(들):
(R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C5H6O5Na2
CAS 번호:
Molecular Weight:
192.08
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
5318041
제품 이름
D-α-Hydroxyglutaric acid disodium salt, ≥95% (GC)
Quality Level
assay
≥95% (GC)
form
powder
color
white to off-white
application(s)
cell analysis
peptide synthesis
storage temp.
−20°C
SMILES string
[Na].O[C@H](CCC(O)=O)C(O)=O
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1
InChI key
DZHFTEDSQFPDPP-HWYNEVGZSA-L
Application
D-α-Hydroxyglutaric acid disodium salt can be used as a reagent in peptide synthesis.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
프로토콜
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
Shan Jin et al.
Nature communications, 14(1), 6638-6638 (2023-10-21)
Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD) and determine the crystal
M Hans et al.
European journal of biochemistry, 265(1), 404-414 (1999-09-22)
Component D (HgdAB) of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum was purified to homogeneity. It is able to use component A from Acidaminococcus fermentans (HgdC) to initiate catalysis together with ATP, Mg2+ and a strong reducing agent such as Ti(III)citrate. Component
The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.
Liu Y, Gilbert MR, Kyprianou N, et al.
Acta Neuropathologica, 128(5), 723-732 (2014)