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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C17H32D5NO
CAS 번호:
Molecular Weight:
276.51
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
제품 이름
1-desoxymethylsphinganine-d5, 1-desoxymethylsphinganine-d5 (m17:0), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860476P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860476P
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@](CN)([H])CCCCCCCCCCCCCC(C([2H])([2H])[2H])([2H])[2H]
InChI key
UGVBFHUWZNNKIK-RPRHKWDUSA-N
General description
Desoxymethylsphinganine is a are the major sphingoid-base present in mammals.
Application
1-desoxymethylsphinganine-d5 may be used as an internal standard for the sphingoid analysis from plasma and tissue.
Biochem/physiol Actions
Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1), due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine.
Packaging
5 mL Amber Glass Screw Cap Vial (860476P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids
wgk
WGK 3
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1
Garofalo K, et al.
The Journal of Clinical Investigation, 121(12), 4735-4745 (2011)
Gergely Karsai et al.
The Journal of biological chemistry, 295(7), 1889-1897 (2019-12-22)
Sphingolipids (SLs) are structurally diverse lipids that are defined by the presence of a long-chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB) (mostly d18:1), whereas the dienic LCB sphingadienine (d18:2) contains a second DB at
Biophysical properties of novel 1-deoxy-(dihydro) ceramides occurring in mammalian cells
Jimenez-Rojo N, et al.
Biophysical Journal, 107(12), 2850-2859 (2014)