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Merck

05-647

Anti-Tyrosinase Antibody, clone T311

clone T311, Upstate®, from mouse

동의어(들):

Anti-Anti-ATN, Anti-Anti-CMM8, Anti-Anti-OCA1, Anti-Anti-OCA1A, Anti-Anti-OCAIA, Anti-Anti-SHEP3

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크기 선택


제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
T311, monoclonal
Application:
IHC, WB
Citations:
12
기술 서비스
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도움 문의
기술 서비스
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도움 문의

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

T311, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable, western blot: suitable

isotype

IgG2a

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

General description

70-80kDa

Immunogen

Purified recombinant Tyrosinase corresponding to residues 5-456 of human Tyrosinase

Application

Not recommended for Immunoprecipitation
Research Category
Neuroscience
Research Sub Category
Neurofilament & Neuron Metabolism

Neuronal & Glial Markers
This Anti-Tyrosinase Antibody, clone T311 is validated for use in WB, IH for the detection of Tyrosinase.

Biochem/physiol Actions

Tyrosinase

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Chromatography

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot on RIPA lysates from SK-MEL-19 cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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저장 등급

10 - Combustible liquids

wgk

WGK 1


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach.
Vad NM, Kandala PK, Srivastava SK, Moridani MY
Chemico-Biological Interactions null
Hee-Sun Lim et al.
Chonnam medical journal, 52(1), 45-52 (2016-02-13)
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and diverse oxidative stimuli. However, few studies have examined the role
Y T Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8125-8129 (1995-08-29)
Tyrosinase (EC 1.14.18.1), the key enzyme in melanin synthesis, has been shown to be one of the targets for cytotoxic T-cell recognition in melanoma patients. To develop serological reagents useful for immunophenotyping melanoma for tyrosinase, human tyrosinase cDNA was expressed
Shashi K Kudugunti et al.
Chemico-biological interactions, 188(1), 1-14 (2010-08-06)
In the current work, we investigated the in vitro biochemical mechanism of Caffeic Acid Phenylethyl Ester (CAPE) toxicity and eight hydroxycinnamic/caffeic acid derivatives in vitro, using tyrosinase enzyme as a molecular target in human SK-MEL-28 melanoma cells. Enzymatic reaction models
Christina Michailidou et al.
Disease models & mechanisms, 2(7-8), 399-411 (2009-05-28)
Deregulated Ras signalling is implicated in most human neoplasia, exemplified by melanoma. Whereas Raf activation occurs almost ubiquitously in benign and malignant melanocytic neoplasms, implying an involvement in tumour initiation, phosphoinositide 3-kinase (PI3K) activation occurs predominantly in malignant neoplasms, implying

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