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Merck

06-501

Anti-STAT1 Antibody, CT

Upstate®, from rabbit

동의어(들):

Anti-CANDF7, Anti-IMD31A, Anti-IMD31B, Anti-IMD31C, Anti-ISGF-3, Anti-STAT91

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
EMSA, IP, WB
Citations:
48

주요 문서

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기술 서비스
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도움 문의

biological source

rabbit

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

electrophoretic mobility shift assay: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_007315

UniProt accession no.

P42224

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... STAT1(6772)

General description

91 kDa
STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway.

STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

Immunogen

GST fusion-protein containing the carboxy terminal 36 amino acids of human STAT1α

Application

Detect STAT1 also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1 Antibody, CT (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA, IP & WB.

Biochem/physiol Actions

Recognizes STAT1.

Physical form

Format: Purified

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
routinely evaluated by immunoblot on RIPA lysates from human Jurkat cells, mouse CTLL or rat L6 cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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저장 등급

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Saehyung Lee et al.
Frontiers in pharmacology, 9, 1568-1568 (2019-02-09)
The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of
Thrombopoietin signal transduction in purified murine megakaryocytes.
Drachman, J G, et al.
Blood, 89, 483-492 (1997)
A F Wilks et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 16(5), 313-320 (1994-05-01)
Cytokine receptors fall into two basic classes: those with their own intrinsic protein tyrosine kinase (PTK) domain, and those lacking a PTK domain. Nonetheless, PTK activity plays a fundamental role in the signal transduction processes lying downstream of both classes
IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.
Sriram, U; Xu, J; Chain, RW; Varghese, L; Chakhtoura, M; Bennett, HL; Zoltick, PW; Gallucci, S
Testing null
Laura R H Ahlers et al.
PloS one, 11(11), e0166088-e0166088 (2016-11-09)
Insects are not only major vectors of mammalian viruses, but are also host to insect-restricted viruses that can potentially be transmitted to mammals. While mammalian innate immune responses to arboviruses are well studied, less is known about how mammalian cells
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관련 콘텐츠

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

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06-50104053252285158

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