205531
CA-074 Me
≥98% (HPLC), solid, Cathepsin B inhibitor, Calbiochem®
동의어(들):
CA-074 Me, Cathepsin B Inhibitor IV, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H31N3O6
Molecular Weight:
397.47
UNSPSC Code:
12352200
NACRES:
NA.77
제품 이름
CA-074 Me, CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable analog of CA-074 (Cat. No. 205530 ) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cathepsin B
cathepsin B
Product does not compete with ATP.
Reversible: no
Target IC50: 2.24 nM against cathepsin B
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sever, N., et al. 2002. Biol. Chem.383, 839.
Authier, F., et al. 1999. J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Authier, F., et al. 1999. J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Carolina Duarte et al.
Journal of cellular and molecular medicine, 26(10), 2841-2851 (2022-04-17)
Emerging studies indicate that intracellular eukaryotic ceramide species directly activate cathepsin B (CatB), a lysosomal-cysteine-protease, in the cytoplasm of osteoclast precursors (OCPs) leading to elevated RANKL-mediated osteoclastogenesis and inflammatory osteolysis. However, the possible impact of CatB on osteoclastogenesis elevated by
Michael C Yoon et al.
Biochemistry, 61(4), 228-238 (2022-02-05)
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human disease mechanisms involves its
Qi Feng Lin et al.
Journal of virology, 97(10), e0082823-e0082823 (2023-09-25)
Reoviruses infect many mammals and are widely studied as a model system for enteric viruses. However, most of our reovirus knowledge comes from laboratory strains maintained on immortalized L929 cells. Herein, we asked whether naturally circulating reoviruses possess the same
Katia Fettucciari et al.
Cellular and molecular life sciences : CMLS, 79(8), 442-442 (2022-07-22)
Clostridioides difficile infection (CDI) causes nosocomial/antibiotic-associated gastrointestinal diseases with dramatically increasing global incidence and mortality rates. The main C. difficile virulence factors, toxins A and B (TcdA/TcdB), cause cytopathic/cytotoxic effects and inflammation. We demonstrated that TcdB induces caspase-dependent, mitochondria-independent enteric
Pin Li et al.
EMBO molecular medicine, 14(1), e14511-e14511 (2021-11-16)
In the course of our studies aiming to discover vascular bed-specific endothelial cell (EC) mitogens, we identified leukemia inhibitory factor (LIF) as a mitogen for bovine choroidal EC (BCE), although LIF has been mainly characterized as an EC growth inhibitor
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 205531-1MGCN | 07790788048433 |
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