217570
Anti-CD3 Mouse mAb (UCHT1)
liquid, >95% (immunoglobulin, SDS-PAGE), clone UCHT1
๋์์ด(๋ค):
Anti-CD3 Antibody, CD3 Detection Antibody, Mouse Anti-CD3
์กฐ์ง ๋ฐ ๊ณ์ฝ ๊ฐ๊ฒฉ์ ๋ณด๋ ค๋ฉด ๋ก๊ทธ์ธ๋ฅผ ํด๋ฆญํฉ๋๋ค.
ํฌ๊ธฐ ์ ํ
์ ํ์ ๋ณด (DICE ๋ฐฐ์ก ์ ๋น์ฉ ๋ณ๋)
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
UCHT1, monoclonal
Species reactivity:
human
Application:
โ
Citations:
7
๊ธฐ์ ์๋น์ค
๋์์ด ํ์ํ์ ๊ฐ์? ์ ํฌ ์๋ จ๋ ๊ณผํ์ ํ์ด ๋์๋๋ฆฌ๊ฒ ์ต๋๋ค.
๋์ ๋ฌธ์๊ธฐ์ ์๋น์ค
๋์์ด ํ์ํ์ ๊ฐ์? ์ ํฌ ์๋ จ๋ ๊ณผํ์ ํ์ด ๋์๋๋ฆฌ๊ฒ ์ต๋๋ค.
๋์ ๋ฌธ์biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
UCHT1, monoclonal
assay
>95% (immunoglobulin, SDS-PAGE)
form
liquid
contains
0.5 mg/mL gentamycin sulfate as preservative
species reactivity
human
manufacturer/tradename
Calbiochemยฎ
storage condition
OK to freeze
dilution
(Flow Cytometry (5 ยตg/mL)
Frozen Sections
Immunoprecipitation
T cell Co-stimulation )
isotype
IgG1
shipped in
wet ice
storage temp.
2-8ยฐC
target post-translational modification
unmodified
Quality Level
Application
Flow Cytometry (5 ยตg/ml)
Frozen Sections (see comments)
Immunoprecipitation (see comments)
T cell Co-stimulation (see application references)
Frozen Sections (see comments)
Immunoprecipitation (see comments)
T cell Co-stimulation (see application references)
Disclaimer
Toxicity: Standard Handling (A)
General description
Anti-CD3, mouse monoclonal, clone UCHT1, recognizes the ฮต-chain of the CD3 complex in human peripheral T cells. It is validated for FC, IP, IHC on frozen sections, and T cell co-stimulation.
Protein A purified mouse monoclonal antibody. Recognizes the ~20 kDa ฮต chain of the CD3 T-cell receptor complex.
Recognizes the ฮต-chain of the CD3 complex in human peripheral T cells. Can be used to activate T cells expressing CD3ฮต.
Immunogen
human thymocytes/Sezary T cells
Other Notes
Thibault, G. and Bardos, P. 1995. J. Immunol.154, 3814.
Beverley, P.C., and Callard, R.E. 1981. Eur. J. Immunol.11, 329.
Beverley, P.C., and Callard, R.E. 1981. Eur. J. Immunol.11, 329.
This antibody can be used to activate T cells expressing CD3ฮต (see application reference). FACS was performed on 5 x 105 cultured HPB-MLT human tumor cells. Optimal binding concentration tested was 5 ยตg/ml when used with secondary reagent goat anti-mouse IgG, FITC conjugated. This antibody is reported to work for immunoprecipitation and for staining frozen sections. Variables associated with assay conditions will dictate the proper working dilution.
Packaging
Please refer to vial label for lot-specific concentration.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
์ ํฉํ ์ ํ์ ์ฐพ์ ์ ์์ผ์ ๊ฐ์? ย
๋น์ฌ์ ์ ํ ์ ํ๊ธฐ ๋๊ตฌ.์(๋ฅผ) ์๋ํด ๋ณด์ธ์.
์ ์ฅ ๋ฑ๊ธ
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
์ํ ์ฑ์ ์(COA)
์ ํ์ ๋กํธ/๋ฐฐ์น ๋ฒํธ๋ฅผ ์ ๋ ฅํ์ฌ ์ํ ์ฑ์ ์(COA)์ ๊ฒ์ํ์ญ์์ค. ๋กํธ ๋ฐ ๋ฐฐ์น ๋ฒํธ๋ ์ ํ ๋ผ๋ฒจ์ ์๋ โ๋กํธโ ๋๋ โ๋ฐฐ์นโ๋ผ๋ ์ฉ์ด ๋ค์์ ์ฐพ์ ์ ์์ต๋๋ค.
์ด ์ ํ์ ์ด๋ฏธ ๊ฐ์ง๊ณ ๊ณ์ญ๋๊น?
๋ฌธ์ ๋ผ์ด๋ธ๋ฌ๋ฆฌ์์ ์ต๊ทผ์ ๊ตฌ๋งคํ ์ ํ์ ๋ํ ๋ฌธ์๋ฅผ ์ฐพ์๋ณด์ธ์.
Wenmin Ji et al.
American journal of cancer research, 13(11), 5218-5235 (2023-12-07)
This research is dedicated to investigating the mechanism of programmed cell death ligand 1 (PD-L1) and tumor protein 53 target gene 1 (TP53TG1) in immune regulation of colon cancer (CC). Expressions of TP53TG1, PD-L1 and signal transducers and activators of
Mengting Chen et al.
International journal of biological sciences, 19(16), 5160-5173 (2023-11-06)
Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and
Xiaofei Gao et al.
Frontiers in immunology, 13, 799331-799331 (2022-03-18)
Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a
Zijun Wang et al.
The Journal of clinical investigation, 130(7), 3717-3733 (2020-03-20)
T follicular helper (Tfh) cells are indispensable for the formation of germinal center (GC) reactions, whereas T follicular regulatory (Tfr) cells inhibit Tfh-mediated GC responses. Aberrant activation of Tfh cells contributes substantially to the pathogenesis of autoimmune diseases, such as
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
Javier Robles-Valero et al.
The EMBO journal, 40(22), e108125-e108125 (2021-10-08)
Mutations in VAV1, a gene that encodes a multifunctional protein important for lymphocytes, are found at different frequencies in peripheral T-cell lymphoma (PTCL), non-small cell lung cancer, and other tumors. However, their pathobiological significance remains unsettled. After cataloguing 51 cancer-associated
๊ตญ์ ๋ฌด์ญ ํ๋ชฉ ๋ฒํธ
| SKU | GTIN |
|---|---|
| 217570-100UGCN | 04055977219418 |
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