218705
Casein Kinase I Inhibitor, D4476
InSolution, ≥95%
동의어(들):
InSolution Casein Kinase I Inhibitor, D4476
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C23H18N4O3
Molecular Weight:
398.41
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze
desiccated (hygroscopic)
protect from light
desiccated (hygroscopic)
protect from light
제품 이름
Casein Kinase I Inhibitor, D4476, InSolution, ≥95%
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CK1, CK1d
CK1, CK1d
Product competes with ATP.
Reversible: no
Target IC50: 0.2 µM, 0.3 µM against CK1, CK1d, respectively
Disclaimer
Toxicity: Irritant (B)
General description
A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
Other Notes
Rena, G., et al. 2004. EMBO Reports5, 60.
Packaging
Packaged under inert gas
Please refer to vial label for lot-specific concentration.
Physical form
A 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
Preparation Note
Following initial use, aliquot and refrigerate (4°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ali Vural et al.
Journal of cell science, 133(17) (2020-08-02)
Activator of G-protein signaling 3 (AGS3, encoded by GPSM1) was discovered as a one of several receptor-independent activators of G-protein signaling, which are postulated to provide a platform for divergence between canonical and noncanonical G-protein signaling pathways. Similarly, Dishevelled (DVL)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 218705-1MGCN | 04055977202540 |
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