324895
eIF-2α Inhibitor, Salubrinal
eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.
동의어(들):
eIF-2α Inhibitor, Salubrinal, Sal
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C21H17Cl3N4OS
CAS 번호:
Molecular Weight:
479.81
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
General description
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
elF-2α
elF-2α
Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM preventing HSV replication both in Vero cells.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Boyce, M., et al. 2005. Science307, 935.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
YongYao Xu et al.
PloS one, 17(7), e0271656-e0271656 (2022-07-29)
Inflammatory signaling induces barrier dysfunction in retinal-pigmented epithelium (RPE) cells and plays a role in the pathology of age-related macular degeneration (AMD). We studied the role of Zn flux from the endoplasmic reticulum (ER) to the cytoplasm via Zip7 during
Ziwei Zhang et al.
Molecular nutrition & food research, 66(5), e2100791-e2100791 (2021-12-31)
To investigate the role of endoplasmic reticulum stress (ERS)-induced autophagy in inflammatory bowel disease (IBD) and the intervention mechanism of Portulaca oleracea L. (POL) extract, a medicinal herb with anti-inflammatory, antioxidant, immune-regulating, and antitumor properties, in vitro and in vivo.
Ting Zhu et al.
Veterinary research, 52(1), 148-148 (2021-12-22)
Viruses have evolved multiple strategies to manipulate their host's translational machinery for the synthesis of viral proteins. A common viral target is the alpha subunit of eukaryotic initiation factor 2 (eIF2α). In this study, we show that global protein synthesis
Ai-Ling Tian et al.
Cell death & disease, 12(1), 6-6 (2021-01-09)
The integrated stress response manifests with the phosphorylation of eukaryotic initiation factor 2α (eIF2α) on serine residue 51 and plays a major role in the adaptation of cells to endoplasmic reticulum stress in the initiation of autophagy and in the
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.