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Merck

329600

Erastin

≥98% (HPLC), solid, ferroptosis inducer, Calbiochem®

동의어(들):

Erastin, 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C30H31ClN4O4
CAS 번호:
571203-78-6
Molecular Weight:
547.04
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09837984

주요 문서

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제품 이름

Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

SMILES string

Clc1ccc(cc1)OCC(=O)N2CCN(CC2)C(C)c3[n]([c](c5c(n3)cccc5)=O)c4c(cccc4)OCC

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI key

BKQFRNYHFIQEKN-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

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관련 카테고리

General description

A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Yagoda, N., et al. 2007. Nature447, 864.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.
Eikan Mishima et al.
Nature, 619(7968), E9-E18 (2023-07-06)
Zhenyi Su et al.
Nature cancer, 4(4), 564-581 (2023-03-28)
Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic screen, we identified BACH1 as a cellular factor that recognizes the
Jiashuo Zheng et al.
Cell death & disease, 12(7), 698-698 (2021-07-15)
Sorafenib, a protein kinase inhibitor approved for the treatment of hepatocellular carcinoma and advanced renal cell carcinoma, has been repeatedly reported to induce ferroptosis by possibly involving inhibition of the cystine/glutamate antiporter, known as system xc-. Using a combination of
Zhuhui Yuan et al.
Oxidative medicine and cellular longevity, 2022, 3403009-3403009 (2022-10-21)
Ionizing radiation-derived oxidative stress and ferroptosis are one of the most important biological effects on destroying the liver tumor, whereas radioresistance of liver tumor remains a leading cause of radiotherapy (RT) failure mainly because of the protective antiferroptosis, in which
Natalie K Horvat et al.
ACS nano, 18(17), 11025-11041 (2024-04-17)
ALK-positive NSCLC patients demonstrate initial responses to ALK tyrosine kinase inhibitor (TKI) treatments, but eventually develop resistance, causing rapid tumor relapse and poor survival rates. Growing evidence suggests that the combination of drug and immune therapies greatly improves patient survival;
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국제 무역 품목 번호

SKUGTIN
329600-5MGCN04055977195651

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