373260
Heat Shock Protein Inhibitor I
Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.
동의어(들):
Heat Shock Protein Inhibitor I, KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C13H11NO4
CAS 번호:
Molecular Weight:
245.23
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze
protect from light
protect from light
제품 이름
Heat Shock Protein Inhibitor I, Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.
InChI key
LZGGUFLRKIMBDQ-UHFFFAOYSA-N
SMILES string
N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to light yellow
solubility
DMSO: 3 mg/mL
olive oil: soluble
shipped in
ambient
storage temp.
−20°C
Quality Level
Disclaimer
Toxicity: Harmful (C)
Biochem/physiol Actions
Cell permeable: no
Primary Target
Hsp70
Hsp70
Product does not compete with ATP.
Reversible: no
General description
A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.
A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
Other Notes
Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.
Yokota, S., et al. 2000. Cancer Res.60, 2942.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 373260-5MGCN | 04055977191004 |
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