407325
Interferon-α-IFNα-R Interaction Inhibitor
The Interferon-α-IFNα-R Interaction Inhibitor controls the biological activity of Interferon-α-IFNα-R.
동의어(들):
Interferon-α-IFNα-R Interaction Inhibitor, IFN-α Inhibitor, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, IFN-α Inhibitor
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H17NS · xHCl
Molecular Weight:
279.40 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.32
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
DMSO: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
SMILES string
CNCC1=CC=CC=C1SC2=CC=CC3=C2C=CC=C3.[xHCl]
General description
A nonpeptidic thiophenylmethanamine compound that binds interferon-α (Kd = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC50<4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Geppert, T., et al. 2011. Angew. Chem. Int. Ed.51, 258.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Debasis Nayak et al.
iScience, 25(5), 104193-104193 (2022-04-29)
The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion/cation transporter
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 407325-25MGCN | 04055977188349 |