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Merck

511075

Platelet Activating Factor-16

≥98% (TLC), lyophilized solid, inflammation mediator, Calbiochem®

동의어(들):

Platelet Activating Factor-16, PAF (C16), 1-O-Palmityl-2-acetyl- sn-glycero-3-phosphocholine, 1-O-Hexadecyl-2-acetyl- sn-glycero-3-phosphocholine, PAF (C16), 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C26H54NO7P
CAS 번호:
74389-68-7
Molecular Weight:
523.68
MDL number:
MFCD00043214
UNSPSC Code:
12352211
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze, desiccated

주요 문서

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제품 이름

Platelet Activating Factor-16, A potent mediator of inflammation that increases vascular permeability. Activates MAP kinases and MAP kinase kinase (MEK) in CHO cells.

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)C)COCCCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

InChI key

HVAUUPRFYPCOCA-AREMUKBSSA-N

assay

≥98% (TLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white to off-white

solubility

ethanol: 0.5-1 mg/mL, water: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

관련 카테고리

General description

Synthetic water-soluble platelet activating factor. A potent mediator of inflammation that increases vascular permeability. Activates MAP kinase and MAP kinase kinase (MEK) in CHO cells.
Synthetic. A potent mediator of inflammation that increases vascular permeability. Activates MAP kinases and MAP kinase kinase (MEK) in CHO cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MAP kinases and MAP kinase kinase (MEK)
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C or -70°C) under an inert gas. Aqueous stock solutions are stable for up to 3 days at -20°C. Ethanol stock solutions are stable for up to 3 months at -70°C.

Other Notes

Honda, Z., et al. 1994. J. Biol. Chem. 269, 2307.
Mori, M., et al. 1994. Ann. N.Y. Acad. Sci.744, 107.
Pinckard, R.N., et al. 1992. J. Immunol.148, 3528.
Salari, H., et al. 1992. Biochem. Cell Biol.70, 129.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

R H Adamson et al.
American journal of physiology. Heart and circulatory physiology, 285(1), H406-H417 (2003-03-22)
We tested the hypothesis that acutely induced hyperpermeability is dependent on actin-myosin contractility by using individually perfused mesentery venules of pentobarbital-anesthetized rats. Venule hydraulic conductivity (Lp) was measured to monitor hyperpermeability response to the platelet-activating factor (PAF) 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine or bradykinin.
Emily A Henderson et al.
Frontiers in immunology, 15, 1363962-1363962 (2024-03-22)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer associated with an immunosuppressive environment. Neutrophil extracellular traps (NETs) were initially described in the context of infection but have more recently been implicated in contributing to the tolerogenic immune response in PDAC.

국제 무역 품목 번호

SKUGTIN
511075-1MGCN04055977272000
511075-5MGCN07790788050894

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