540223
Purmorphamine
≥98% (HPLC), liquid, Hedgehog signaling activator, Calbiochem
동의어(들):
InSolution Purmorphamine, Purmorphamine
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C31H32N6O2
UNSPSC Code:
12352116
NACRES:
NA.77
제품 이름
Purmorphamine, InSolution, ≥98%, 50 mM in DMSO, induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
storage temp.
−20°C
Quality Level
관련 카테고리
General description
A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC50 = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.
Purmorphamine is a cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells.
Application
InSolution Purmorphamine, CAS 483367-10-8, is a provided as a 50 mM solution in DMSO. Induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 & lineage-committed preosteoblasts MC3T3-E1.
Packaging
Packaged under inert gas
Physical form
A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540220) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Wu, X., et al. 2004. Chem. Biol.11, 1229.
Wu, X., et al. 2002. J. Am. Chem. Soc.124, 14520.
Wu, X., et al. 2002. J. Am. Chem. Soc.124, 14520.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
signalword
Warning
hcodes
Hazard Classifications
Muta. 2
저장 등급
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Megumi Kitami et al.
Biochemical and biophysical research communications, 509(1), 222-226 (2018-12-28)
Condylar cartilage is a joint cartilage essential for smooth jaw movement. The importance of ciliary proteins in condylar cartilage development has been reported. However, little is known about how ciliary proteins control the homeostasis of condylar cartilage. Here we show
Arens Taga et al.
Journal of visualized experiments : JoVE, (174) (2021-09-14)
Human pluripotent stem cell-derived astrocytes (hiPSC-A) and neurons (hiPSC-N) provide a powerful tool for modeling Amyotrophic Lateral Sclerosis (ALS) pathophysiology in vitro. Multi-electrode array (MEA) recordings are a means to record electrical field potentials from large populations of neurons and
Aurelie de Rus Jacquet et al.
eLife, 10 (2021-10-01)
Astrocytes are essential cells of the central nervous system, characterized by dynamic relationships with neurons that range from functional metabolic interactions and regulation of neuronal firing activities, to the release of neurotrophic and neuroprotective factors. In Parkinson's disease (PD), dopaminergic
Inge Kinnart et al.
NPJ Parkinson's disease, 10(1), 80-80 (2024-04-10)
The pathogenic effect of SNCA gene multiplications indicates that elevation of wild-type α-synuclein levels is sufficient to cause Parkinson's disease (PD). Mitochondria have been proposed to be a major target of α-synuclein-induced damage. PINK1/parkin/DJ-1-mediated mitophagy is a defense strategy that
Jennifer Pardieck et al.
Stem cell research & therapy, 13(1), 131-131 (2022-03-30)
Spinal interneurons (INs) relay sensory and motor control information between the brain and body. When this relay circuitry is disrupted from injury or disease, it is devastating to patients due to the lack of native recovery in central nervous system
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 540223-5MGCN | 04055977268782 |
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.