654255
TNF-α Antagonist
≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem®
동의어(들):
TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C58H71N11O15S2
Molecular Weight:
1226.38
UNSPSC Code:
12352200
NACRES:
NA.77
제품 이름
TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
solubility
water: 1 mg/mL
5% acetic acid: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5 µM as TNF-α antagonist
Disclaimer
Toxicity: Standard Handling (A)
General description
An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
Legal Information
Sold under license of U.S. Patent 6,265,535.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 654255-1MGCN | 04055977184624 |
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