AB1926
Anti-Integrin beta 5 (ITGB5) Antibody
CHEMICON®, rabbit polyclonal
동의어(들):
Anti-Anti-AA475909, Anti-Anti-AI874634, Anti-Anti-ESTM23, Anti-Anti-[b]-5, Anti-Anti-[b]5, Anti-Anti-[b]5A, Anti-Anti-[b]5B, Anti-Anti-beta-5, Anti-Anti-beta5
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
mouse, hamster, human, rat
Application:
ELISA, IF, IHC, IP, RIA, WB
Citations:
41
제품 이름
Anti-Integrin β5 Antibody, CT/cytosolic, serum, Chemicon®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, hamster, human, rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunofluorescence: suitable, immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable, radioimmunoassay: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGB5(3693)
mouse ... Itgb5(16419)
rat ... Itgb5(257645)
General description
88 kDa
The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented.
The beta5 subunit associates with alphaV forming a receptor for vitronectin. This complex is expressed in a wide range of cell types including fibroblast and keratinocytes. It is also expressed at high levels in several tumors including lung, pancreatic and mammary carcinomas. It is not expressed in lymphblastoid cells.
The beta5 subunit associates with alphaV forming a receptor for vitronectin. This complex is expressed in a wide range of cell types including fibroblast and keratinocytes. It is also expressed at high levels in several tumors including lung, pancreatic and mammary carcinomas. It is not expressed in lymphblastoid cells.
Immunogen
Epitope: C-terminus/cytosolic
Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human integrin beta 5 subunit (KTFNKFNKSYNGTVD). Note : a lysine (K) residue was added to the N-terminal of the peptide to facilitate coupling to the carrier protein.
Application
Detect Integrin β5 using this Anti-Integrin β5 Antibody, C-terminus/cytosolic validated for use in ELISA, IF, IH(P), IP, RIA & WB.
ELISA/RIA
Immunoprecipitation: 5μL of antibody is sufficient to precipitate alphaVbeta5 from
2.5x10E6 cells.
Western blot: non-reduced conditions; do not use milk in the dilution buffer.
Immunofluorescence: 1:100.
Immunohistochemistry (Acetone Fixed) 1:40-1:80
Immunohistochemistry (Paraffin Embedded) 1:200 (ABC)
Optimal working dilutions must be determined by end user.
Immunoprecipitation: 5μL of antibody is sufficient to precipitate alphaVbeta5 from
2.5x10E6 cells.
Western blot: non-reduced conditions; do not use milk in the dilution buffer.
Immunofluorescence: 1:100.
Immunohistochemistry (Acetone Fixed) 1:40-1:80
Immunohistochemistry (Paraffin Embedded) 1:200 (ABC)
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Recognizes Integrin beta5. Specificity determined by immunoprecipitation from detergent extract of 35S methionine labeled cells. No cross-reactivity to beta1 or beta3.
Physical form
UnPurified whole rabbit Serum containing 0.05% sodium azide as a preservative.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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저장 등급
10 - Combustible liquids
wgk
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts.
McQuade, KJ; Beauvais, DM; Burbach, BJ; Rapraeger, AC
Journal of Cell Science null
Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization.
Shi, Y; Ethell, IM
The Journal of Neuroscience null
Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation.
Yan, YX; Gong, YW; Guo, Y; Lv, Q; Guo, C; Zhuang, Y; Zhang, Y; Li, R; Zhang, XZ
Testing null
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
Beauvais, DM; Ell, BJ; McWhorter, AR; Rapraeger, AC
The Journal of Experimental Medicine null
K Triantafilou et al.
Journal of virology, 74(13), 5856-5862 (2000-06-14)
Human parechovirus 1 (HPEV1) displays an arginine-glycine-aspartic acid (RGD) motif in the VP1 capsid protein, suggesting integrins as candidate receptors for HPEV1. A panel of monoclonal antibodies (MAbs) specific for integrins alphavbeta3, alphavbeta1, and alphavbeta5, which have the ability to
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| AB1926 | 04053252744846 |
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