CP18
Anti-Collagen Type II (Ab-1) Mouse mAb (II-4C11)
liquid, clone II-4C11, Calbiochem®
동의어(들):
Collagen Type II antibody
제품 이름
Anti-Collagen Type II (Ab-1) Mouse mAb (II-4C11), liquid, clone II-4C11, Calbiochem®
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
II-4C11, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
rat, human, bovine, rabbit
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
dilution
(Frozen Sections (1-10 µg/mL)
Immunoblotting (1-5 µg/mL,
Paraffin Sections (1-10 µg/mL, )
isotype
IgG1
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL2A1(1280)
Application
Frozen Sections (1-10 µg/ml)
Immunoblotting (1-5 µg/ml, see application references)
Paraffin Sections (1-10 µg/ml, see application references)
Immunoblotting (1-5 µg/ml, see application references)
Paraffin Sections (1-10 µg/ml, see application references)
Disclaimer
Toxicity: Standard Handling (A)
General description
Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with P3-X-63-Ag8-LUI mouse myeloma cells. Recognizes the ~130 kDa type II collagen protein.
Recognizes the ~130 kDa type II collagen protein. May react with other collagens. When used at high concentrations higher bands corresponding to aggregates may also be detected.
This Anti-Collagen Type II (Ab-1) Mouse mAb (II-4C11) is validated for use in Frozen Sections for the detection of Collagen Type II (Ab-1).
Immunogen
Human
purified collagen type II
Legal Information
Manufactured by Daiichi Fine Chemical Co., Ltd. Not available for sale in Japan.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Kumagai, J. et al. 1994 J. Anat.185, 278.
Kivrikko, K,I. 1993 Ann. Med.25, 113.
Sandell, L.J., et al. 1991 J. Cell. Biol.114, 1307.
Ryan, M.C., and Sandell, L.J. 1990 J. Biol. Chem.265, 10334.
Mayne, R., and Burgeson, R.E. 1987 Structure and Function of Collagen Types,Academic Press, Orlando, FL
Kivrikko, K,I. 1993 Ann. Med.25, 113.
Sandell, L.J., et al. 1991 J. Cell. Biol.114, 1307.
Ryan, M.C., and Sandell, L.J. 1990 J. Biol. Chem.265, 10334.
Mayne, R., and Burgeson, R.E. 1987 Structure and Function of Collagen Types,Academic Press, Orlando, FL
May react with other collagens. When used at high concentrations higher bands corresponding to aggregates may also be detected. This antibody may also react with other classes of collagen at a concentration higher than 1 µg/ml. In immunoblotting, a major band of ~130 kDa is obtained. Antibody should be titrated for optimal results in individual systems.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 100 mM sodium phosphate buffer, 0.1% BSA, pH 7.0.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
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저장 등급
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Silencing of Wnt5a prevents interleukin-1β-induced collagen type II degradation in rat chondrocytes.
Shiping Shi et al.
Experimental and therapeutic medicine, 12(5), 3161-3166 (2016-11-25)
Osteoarthritis (OA) is a joint disease, and few treatments to date have been able to delay OA progression. The degradation of collagen type II (COL2) in the cartilage matrix is an important initiating factor for OA progression; the upregulation of
Han-Jun Kim et al.
Oxidative medicine and cellular longevity, 2020, 5915481-5915481 (2020-10-09)
Intervertebral disc degeneration (IVDD) is a common cause of lower back pain. Programmed cell death (PCD) including apoptosis and autophagy is known to play key mechanistic roles in the development of IVDD. We hypothesized that the nucleus pulposus cells that
María Satué et al.
Scientific reports, 9(1), 10153-10153 (2019-07-14)
Intra-articular (IA) injection of mesenchymal stem cells (MSCs) promotes articular cartilage repair. However, cell fate and action after transplantation remain unclear. This study aimed at evaluating the biodistribution and efficacy of MSCs after IA injection. We used an immunocompetent, dual
En-Rung Chiang et al.
PloS one, 11(2), e0149835-e0149835 (2016-02-26)
Mesenchymal stem cell (MSC)-based therapies may aid in the repair of articular cartilage defects. The purpose of this study was to investigate the effects of intraarticular injection of allogeneic MSCs in an in vivo anterior cruciate ligament transection (ACLT) model
En-Rung Chiang et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(6), 1440-1450 (2019-05-08)
Intervertebral discs (IVDs) are important biomechanical components of the spine. Once degenerated, mesenchymal stem cell (MSC)-based therapies may aid in the repair of these discs. Although hypoxic preconditioning enhances the chondrogenic potential of MSCs, it is unknown whether bone marrow
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| CP18-100UGCN | 04055977220957 |
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