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Merck

MAB8188

Anti-EBV EA-R-p17 Antibody, clone 5B11

clone 5B11, Chemicon®, from mouse

동의어(들):

Early Antigen Protein R, Nuclear Antigen, BHRF1

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크기 선택


제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
5B11, monoclonal
Species reactivity:
human
Application:
ELISA, IF, IP, WB
Citations:
16
기술 서비스
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도움 문의

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5B11, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable, immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG2a

shipped in

wet ice

Quality Level

General description

The Early Restricted protein (Ea-R) of Epstein-Bar Virus is encoded by the viral BHFR1 gene. Ea-R is a 17 kDa protein (p17) with protein kinase activity. Ea-R-p17 is a functional homologue of the anti-apoptotic oncoprotein bcl-2, which is expressed during the switch from latency to lytic replication and may be involved in proliferation of EBV infected cells. However, Ea-R-p17 does not appear to be essential for virus replication or transformation of B cells in vitro.

Application

Anti-EBV EA-R-p17 Antibody, clone 5B11 is an antibody against EBV EA-R-p17 for use in ELISA, IF, IP & WB.
Immunoblotting

Immunoprecipitation

Immunofluorescence

Optimal dilutions must be determined by the end user.
Research Category
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral

Biochem/physiol Actions

Recognizes the 17 kDa Early Restricted Protein (Ea-R-p17) of Epstein-Barr Virus by immunoblot, immunoprecipitation and immunofluorescence.

Physical form

Format: Purified
Purified immunoglobulin presented as a liquid in 0.02M PBS, 0.25M NaCl, with 0.1% sodium azide.

Preparation Note

Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

저장 등급

12 - Non Combustible Liquids


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Mingxia Shi et al.
Virus research, 177(1), 11-21 (2013-07-31)
Transition of Akata Burkitt's lymphoma (BL) from a malignant to nonmalignant phenotype upon loss of Epstein-Barr virus (EBV) is evidence for a viral contribution to tumorigenesis despite the tight restriction of EBV gene expression in BL. Examination of global cellular
Comparative analysis of the expression of the Epstein-Barr virus (EBV) anti-apoptotic gene BHRF1 in nasopharyngeal carcinoma and EBV-related lymphoid diseases
Nicholls, J. et al.
Journal of Medical Virology, 65, 105-113 (2001)
C A Meseda et al.
The Journal of general virology, 81(Pt 7), 1801-1805 (2000-06-22)
The human tumour virus Epstein-Barr virus (EBV) encodes a 17 kDa protein, BHRF1, which is a member of the BCL:-2 family and has been shown to suppress apoptosis. The role of this gene in the life-cycle of EBV has not
Functional differences between BHRF1, the Epstein-Barr virus-encoded Bcl-2 homologue, and Bcl-2 in human epithelial cells
Dawson, C. et al.
Journal of virology, 72, 9016-9024 (1998)
Epstein-Barr virus contributes to the malignant phenotype and to apoptosis resistance in Burkitt's lymphoma cell line Akata.
J Komano, M Sugiura, K Takada
Journal of virology null

국제 무역 품목 번호

SKUGTIN
MAB818804053252502439

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