IGROV-1 Human Ovarian Cancer Cell Line

The IGROV-1 cell line is well-established as a model for drug-resistant ovarian carcinoma. IGROV-1 cells lack hormone receptors and exhibit low to moderate sensitivity to several common chemotherapeutic agents, while remaining sensitive to cisplatin (1). IGROV-1 cells harbor a paracentric inversion of chromosome 3 and a translocation between chromosomes 2 and 5 (1). The IGROV-1 cell line exhibits hypermutation and has an overall mutation profile similar to endometrioid carcinoma (2). IGROV-1 cells appear in culture as confluent monolayers and are highly tumorigenic in vivo, forming solid tumors within 15 days in nude mice (1). IGROV-1 cells are characterized by expression of vitronectin and αvα3 integrin, essential for the observed migratory behavior of these cells toward ECM proteins (3), and express the cancer-associated target MDM2 (4).

Source:
IGROV-1 cells were established from a stage III ovarian solid primary tumor of a 47-year-old female patient (1).

Research Category:
Cancer

Human, Cancer Cells

≥1X10⁶ cells/vial

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

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