14690
Bis(cyclohexanone)oxaldihydrazone
for spectrophotometric det. of Cu, ≥99.0%
동의어(들):
Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C14H22N4O2
CAS 번호:
Molecular Weight:
278.35
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
EC Number:
206-729-2
Beilstein/REAXYS Number:
2388004
MDL number:
InChI key
DSRJIHMZAQEUJV-UHFFFAOYSA-N
InChI
1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
SMILES string
O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
assay
≥99.0% (N), ≥99.0%
form
powder
quality
for spectrophotometric det. of Cu
technique(s)
UV/Vis spectroscopy: suitable
Quality Level
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General description
Cuprizone (Bis(cyclohexanone)oxaldihydrazone) is a physically unstable compound and is a well-known neurotoxic agent.
Application
Cuprizone (Bis(cyclohexanone)oxaldihydrazone) was used for toxic demyelination in the central nervous system in order to investigate the pathobiology of remyelination in the corpus callosum, so as to study the human demyelinating diseases such as multiple sclerosis. It was also used a model to study components of neuroinflammation.
Other Notes
For the spectrophotometric determination of Cu(II)
In the presence of a copper salt, this ligand catalyzes Ullmann-type C-N bond forming reactions under mild, aqueous conditions.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
R.K. Rohde
Analytical Chemistry, 38, 911-911 (1966)
Zhu, X., et al.
Synthesis, 23, 3955-3962 (2006)
The protective role of nitric oxide in a neurotoxicant-induced demyelinating model.
Arnett H
Journal of Immunology, 168 (1), 427-433 (2002)
Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum.
Groebe A
Cerebellum, 8 (3), 163-174 (2009)
Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.
Thomas S
The American Journal of Pathology, 174 (4), 1053-1061 (2008)
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