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Merck

27102

Citric acid monohydrate

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

동의어(들):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS 번호:
5949-29-1
Molecular Weight:
210.14
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
57648219
EC Number:
201-069-1
Beilstein/REAXYS Number:
4018641
MDL number:
MFCD00149972
Assay:
99.5-100.5% (based on anhydrous substance)
Form:
grit

주요 문서

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InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

grade

puriss.

assay

99.5-100.5% (based on anhydrous substance)

form

grit

quality

meets analytical specification of Ph. Eur., BP, USP, E330

impurities

residual solvents, complies, ≤0.0005% heavy metals (as Pb), 7.5-8.8% water (Karl Fischer)

ign. residue

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤50 mg/kg, oxalate (as oxalic acid): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg, Ca: ≤200 mg/kg, Cu: ≤10 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, Pb: ≤1 mg/kg, Zn: ≤10 mg/kg

suitability

complies for appearance of solution, complies for identity (IR), complies for reaction against H2SO4

functional group

carboxylic acid

Quality Level

200

유사한 제품을 찾으십니까? 방문 제품 비교 안내

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1

Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

11 - Combustible Solids

flash_point_f

345.0 °F - closed cup

flash_point_c

173.9 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCM7252
BCCK3277
BCCH5300
BCCG2090
BCCD2310

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Enthalpy of solution of oxalic, succinic, adipic, maleic, malic, tartaric, and citric acids, oxalic acid dihydrate, and citric acid monohydrate in water at 298.15K.
Apelblat A.
The Journal of Chemical Thermodynamics, 18(4), 351-357 (1986)
S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
Carolina Ganss et al.
PloS one, 10(6), e0123889-e0123889 (2015-06-16)
For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray)
Kristine Opsvik Wikene et al.
Drug development and industrial pharmacy, 41(6), 969-977 (2014-05-21)
Bacterial resistance to antibiotics is increasing and alternative antibacterial treatments like antimicrobial photodynamic therapy (aPDT) are needed. Curcumin is under investigation as a potential photosensitizer in aPDT. The purpose of this study was to develop rapidly dissolving formulations of curcumin
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