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Merck

32103

Posaconazole

VETRANAL®, analytical standard

동의어(들):

4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C37H42F2N8O4
CAS 번호:
171228-49-2
Molecular Weight:
700.78
NACRES:
NA.24
PubChem Substance ID:
329753992
UNSPSC Code:
41116107
MDL number:
MFCD00941162

주요 문서

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기술 서비스
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InChI

1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1

SMILES string

CC[C@@H]([C@H](C)O)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OC[C@@H]5CO[C@@](C5)(Cn6cncn6)c7ccc(F)cc7F)cc4

InChI key

RAGOYPUPXAKGKH-XAKZXMRKSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

Quality Level

100

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관련 카테고리

General description

Posaconazole is an azole antifungal drug used mostly against zygomycetes.

Application

Posaconazole may have been used as reference standard in HPLC analysis for quantification of posaconazole from human plasma.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCN5887
BCCK0662
BCCH9785
BCCC8920
BCCB7317

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리 방문

Michael N Trinh et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), 89-94 (2016-12-21)
Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal cholesterol export is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug [Xu et
Sophida Boonsathorn et al.
Clinical pharmacokinetics, 58(1), 53-61 (2018-04-22)
The objectives of this study were to investigate the population pharmacokinetics of posaconazole in immunocompromised children, evaluate the influence of patient characteristics on posaconazole exposure and perform simulations to recommend optimal starting doses. Posaconazole plasma concentrations from paediatric patients undergoing
Dorival Martins et al.
Scientific reports, 9(1), 9185-9185 (2019-06-27)
Fungi respond to antifungal drugs by increasing their antioxidant stress response. How this impacts antifungal efficacy remains controversial and not well understood. Here we examine the role of catalase activity in the resistance of Saccharomyces cerevisiae to the common antifungals
Shu-Ying Yu et al.
Infection and drug resistance, 11, 1537-1547 (2018-10-06)
Trichosporon dohaense is a rare fungal species that has not been described in human invasive infections. In this study, we investigated two T. dohaense isolates from patients with invasive infections in two hospitals in China, as part of the China
Posaconazole as salvage therapy for zygomycosis.
Greenberg, R. N., et al.
Antimicrobial Agents and Chemotherapy, 50.1, 126-133 (2006)
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