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Merck

33114

Citric acid monohydrate

ACS reagent grade, 99.5-102%, solid, puriss. p.a., reag. ISO, reag. Ph. Eur., buffer substance

동의어(들):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS 번호:
5949-29-1
Molecular Weight:
210.14
NACRES:
NA.21
PubChem Substance ID:
57648756
UNSPSC Code:
12352100
EC Number:
201-069-1
MDL number:
MFCD00149972
Beilstein/REAXYS Number:
4018641
Assay:
99.5-100.5% (calc. on anhydrous substance), 99.5-102%
Form:
solid

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제품 이름

Citric acid monohydrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, 99.5-102%

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

grade

ACS reagent, puriss. p.a.

agency

USP/NF, reag. ISO, reag. Ph. Eur.

assay

99.5-100.5% (calc. on anhydrous substance), 99.5-102%

form

solid

impurities

≤0.005% insolubles in water, ≤2 ppm heavy metals (as Pb), 7.5-9.0% water (Karl Fischer)

ign. residue

≤0.01% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤5 mg/kg, oxalate (C2O42-): ≤100 ppm, phosphate (PO43-): ≤10 mg/kg, sulfate (SO42-): ≤20 ppm

cation traces

Ca: ≤50 mg/kg, Cu: ≤5 mg/kg, Fe: ≤3 ppm, Pb: ≤2 ppm, Zn: ≤5 mg/kg

suitability

complies for appearance of solution, complies for reaction against H2SO4

functional group

carboxylic acid

Quality Level

200

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관련 카테고리

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1.

Application

Citric acid monohydrate may be used in the preparation of tris-citrate buffer and Otto I isolation buffer used in bioprotocols. It may also be used to improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

11 - Combustible Solids

flash_point_f

345.0 °F - closed cup

flash_point_c

173.9 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCP0211
BCCN3805
SDBB2149
STBL3472
SDBB0355

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets.
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International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
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