Quality Level
General description
Awater-soluble embedding medium for EM based on an aliphatic polyepoxide.
Application
- A method to prepare large resin sections for counting myelinated axons in rodent CNS and PNS structures.: This study presents a technique using Durcupan ACM for preparing large resin sections, enhancing the analysis of myelinated axons in rodent central and peripheral nervous systems (Dzurjašková et al., 2021) (Dzurjašková et al., 2021).
- Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues.: This research utilizes Durcupan ACM in electron microscopy to create 3D models of neural tissues, facilitating studies via immersive virtual reality (Calì et al., 2016) (Calì et al., 2016).
- Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR.: Explores the cardiovascular effects in rats using Durcupan ACM embedded samples for detailed tissue analysis (Kristek et al., 2013) (Kristek et al., 2013).
Features and Benefits
Mixtures of Durcupan ACM present an interesting alternative to methacrylates for embedding sections for electron microscopy. They present the advantage that they harden uniformly, practically without shrinkage. All fixing agents normally used for electronmicroscopic work are also suitable for the Durcupan ACM embedding process. This process consists of three phases: dehydration of the tissue with acetone or ethyl alcohol, infiltration with the embedding agent, followed by hardening.
Legal Information
Durcupan is a trademark of Sigma-Aldrich Chemie GmbH
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Danger
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - ED ENV 1 - ED HH 1 - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B - Skin Sens. 1
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Enric Llorens-Bobadilla et al.
Science (New York, N.Y.), 370(6512) (2020-10-03)
Injuries to the central nervous system (CNS) are inefficiently repaired. Resident neural stem cells manifest a limited contribution to cell replacement. We have uncovered a latent potential in neural stem cells to replace large numbers of lost oligodendrocytes in the
Małgorzata Alicja Śliwińska et al.
Cerebral cortex (New York, N.Y. : 1991), 30(4), 2573-2585 (2019-12-05)
It is generally accepted that formation and storage of memory relies on alterations of the structure and function of brain circuits. However, the structural data, which show learning-induced and long-lasting remodeling of synapses, are still very sparse. Here, we reconstruct
Nicholas J Strausfeld et al.
The Journal of comparative neurology, 528(2), 261-282 (2019-08-04)
Brain centers possessing a suite of neuroanatomical characters that define mushroom bodies of dicondylic insects have been identified in mantis shrimps, which are basal malacostracan crustaceans. Recent studies of the caridean shrimp Lebbeus groenlandicus further demonstrate the existence of mushroom