49508
Sinapic acid
suitable for matrix substance for MALDI-MS, ≥99.5%, Ultra pure
동의어(들):
3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C11H12O5
CAS 번호:
Molecular Weight:
224.21
UNSPSC Code:
41115716
NACRES:
NA.21
PubChem Substance ID:
EC Number:
208-487-3
Beilstein/REAXYS Number:
2699118
MDL number:
Assay:
≥99.5% (HPLC), ≥99.5%
InChI
1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13)/b4-3+
InChI key
PCMORTLOPMLEFB-ONEGZZNKSA-N
SMILES string
COc1cc(\C=C\C(O)=O)cc(OC)c1O
assay
≥99.5% (HPLC), ≥99.5%
analyte chemical class(es)
dendrimers, fullerenes, peptides, proteins
technique(s)
MALDI-MS: suitable
mp
~202 °C
solubility
dioxane: 1 g/10 mL at hot, clear, faintly yellow to yellow
cation traces
Al: ≤1 mg/kg, Ba: ≤1 mg/kg, Ca: ≤2 mg/kg, Cd: ≤1 mg/kg, Co: ≤1 mg/kg, Cr: ≤1 mg/kg, Cu: ≤1 mg/kg, Fe: ≤1 mg/kg, K: ≤2 mg/kg, Li: ≤1 mg/kg, Mg: ≤1 mg/kg, Mn: ≤1 mg/kg, Na: ≤2 mg/kg, Ni: ≤1 mg/kg, Sr: ≤1 mg/kg, Zn: ≤1 mg/kg
suitability
in accordance for UV test, suitable for matrix substance for MALDI-MS
Quality Level
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General description
Sinapic acid is one of the 4 most common hydroxycinnamic acids. It is widespread in the plant kingdom (vegetables, fruits, oilseed crops, cereal grains and medicinal plants, and some spices). It is mostly found in the form of esters, but may exist in the free form too.
Application
- Metabolic Fate Characterization: Sinapic acid′s metabolic fate in biological systems is a significant area of research. Recent studies in rats have focused on identifying the metabolic pathways and by-products of sinapic acid, using advanced techniques such as liquid chromatography-mass spectrometry (LC-MS). These studies provide insights into its bioavailability and pharmacokinetics, which are crucial for understanding its therapeutic potential (Analytical and Bioanalytical Chemistry, 2023).
- Efficient Extraction from Plant Materials: Sinapic acid is extracted from various plant sources using molecularly imprinted polymers (MIPs) and deep eutectic solvents. These methods enhance the efficiency and selectivity of sinapic acid extraction, making it a valuable approach for analytical chemists working on natural product isolation and characterization. This application is particularly relevant in the food and pharmaceutical industries for quality control and standardization (Food Chemistry, 2023).
- Selective Sensing Applications: Sinapic acid is used in the development of nanocomposites for selective sensing applications. For instance, Ni-sinapic acid nanocomposites have been developed for the selective detection of permanganate ions. This research showcases the versatility of sinapic acid in creating sensitive and specific sensors for environmental monitoring and analytical applications (Journal of Photochemistry and Photobiology A: Chemistry, 2023).
- Bioactivity Studies: The bioactivity of sinapic acid extends to its anti-inflammatory and anticancer properties. Studies have shown that sinapic acid can modulate various biochemical pathways, providing protective effects against inflammation and cancer. These findings underscore its potential as a bioactive compound in therapeutic formulations and highlight the importance of analytical methods in quantifying its efficacy and safety (Stem Cell Research International, 2022).
Biochem/physiol Actions
On removal of amino group from phenylalanine, catalysing with enzyme phenylalanine ammonia-lyase forms cinnamic acid. The precursor of hydroxycinnamates is produced after hydroxylation of benzene ring. One of the precursors produced is sinapic acid. Sinapic acid exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anti-anxiety activity. Sinapine (sinapoyl choline) has been acknowledged as an acetylcholinesterase inhibitor, making it therapeutically applicable in treatment of various diseases. 4-Vinylsyringol (a decarboxylation product of sinapic acid) is a potent antimutagenic and antioxidative agent, involved in suppressing the induction of inflammatory cytokines and carcinogenesis. Owing to their anti-oxidative activity, these compounds have been considered to be potentially employed in the pharmaceutical industry, cosmetics and food processing.
Sinapic acid was suitable as phenolic standard for HPLC analysis in determination of Sinapic acid derivatives in Canola extracts. 10 g/L of sinapinic acid with solvent was suitable as matrix for ultraviolet laser desorption mass spectrometric determination of proteins. It was also suitable to use as matrix for MALDI-TOFMS and MALDI-ion mobility-TOFMS to determine phospholipids in tissue.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sinapic acid and its derivatives: natural sources and bioactivity.
Niciforovic, Neda, and Helena Abramovic
Comprehensive Reviews in Food Science and Food Safety, 13 (1), 34-51 (2014)
Cinnamic acid derivatives as matrices for ultraviolet laser desorption mass spectrometry of proteins.
Beavis, Ronald C., Brain T. Chait, and H. M. Fales.
Rapid Communications in Mass Spectrometry, 3 (12), 432-435 (1989)
Determination of sinapic acid derivatives in canola extracts using high-performance liquid chromatography.
Khattab, Rabie, et al.
Journal of the American Oil Chemists' Society, 87 (2), 147-155 (2010)
Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS
Jackson SN, Wang HY, Woods AS, Ugarov M, Egan T, Schultz JA.
Journal of the American Society For Mass Spectrometry, 16 (2), 133-138 (2005)
Climate change and crops
Singh, S. N., ed.
Springer Science & Business Media (2009)
문서
One of the most important aspects of our ultra-pure MALDI matrix substances is their ability to dissolve rapidly and completely; a brief vortex mixing is typically sufficient.
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