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Merck

53787

Carazolol

analytical standard

동의어(들):

1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol, 4-(2-Hydroxy-3-isopropylamino-propoxy)carbazole

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C18H22N2O2
CAS 번호:
57775-29-8
Molecular Weight:
298.38
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329757996
EC Number:
260-945-1
Beilstein/REAXYS Number:
3620576
MDL number:
MFCD00864588

주요 문서

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제품 이름

Carazolol, analytical standard

InChI key

BQXQGZPYHWWCEB-UHFFFAOYSA-N

InChI

1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3

SMILES string

CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12

grade

analytical standard

assay

≥98.5% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

mp

133-137 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

Quality Level

200

관련 카테고리

Application

Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Carazolol may be used as a reference standard for the determination of the analyte:
  • In swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
  • In animal tissues by high-performance liquid chromatography with electrochemical detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706030, T706025

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000401292
0000401292
WXBF3309V
0000280507
WXBF1115V

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Tomonaga Ozawa et al.
Bioorganic & medicinal chemistry, 19(17), 5231-5237 (2011-08-09)
We examined CH/π hydrogen bonds using an ab initio fragment molecular orbital (FMO) method, combined with the CHPI program, to evaluate complexes of active (bound with agonist 1) and inactive (bound with inverse agonist 2) β2 adrenergic receptor (β(2)AR) states.
Sid Topiol et al.
Biochemical pharmacology, 78(1), 11-20 (2009-05-19)
G-protein-coupled receptor (GPCR) proteins [Lundstrom KH, Chiu ML, editors. G protein-coupled receptors in drug discovery. CRC Press; 2006] are the single largest drug target, representing 25-50% of marketed drugs [Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are
Determination of residues of carazolol and a number of tranquilizers in swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
Keukens HJ and Aerts MML
Journal of Chromatography A, 464, 149- 161 (1991)
Stefano Costanzi
Journal of medicinal chemistry, 51(10), 2907-2914 (2008-04-30)
The publication of the crystal structure of the beta2-adrenergic receptor (beta2-AR) proved that G protein-coupled receptors (GPCRs) share a structurally conserved rhodopsin-like 7TM core. Here, to probe to which extent realistic GPCR structures can be recreated through modeling, carazolol was
Chris de Graaf et al.
Journal of medicinal chemistry, 51(16), 4978-4985 (2008-08-06)
The recently solved high-resolution X-ray structure of the beta2 adrenergic receptor has been challenged for its ability to discriminate inverse agonists/antagonists from partial/full agonists. Whereas the X-ray structure of the ground state receptor was unsuitable to distinguish true ligands with
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