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Merck

61739

N-Lauroylsarcosine

≥98.0% (GC), suitable for protein quantification, purum p.a.

동의어(들):

N-Dodecanoyl-N-methylglycine, Sarkosyl L

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
CH3(CH2)10CON(CH3)CH2COOH
CAS 번호:
97-78-9
Molecular Weight:
271.40
NACRES:
NA.21
PubChem Substance ID:
57651861
UNSPSC Code:
12352100
EC Number:
202-608-3
MDL number:
MFCD00021749
Beilstein/REAXYS Number:
1792084

주요 문서

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제품 이름

N-Lauroylsarcosine, purum p.a., ≥98.0% (GC)

InChI key

BACYUWVYYTXETD-UHFFFAOYSA-N

InChI

1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

SMILES string

CCCCCCCCCCCC(=O)N(C)CC(O)=O

description

anionic

grade

purum p.a.

assay

≥98.0% (GC)

mol wt

271.40 g/mol

technique(s)

protein quantification: suitable

impurities

≤0.2% water

ign. residue

≤0.1%

mp

45-50 °C

anion traces

chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

Ca: ≤20 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤10 mg/kg, K: ≤70 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤200 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤20 mg/kg

functional group

amide, carboxylic acid

Quality Level

200

관련 카테고리

General description

N-Lauroylsarcosine (N-Dodecanoyl-N-methylglycine, Sarkosyl L, LS) is an anionic surfactant. Its microbicidal action against herpes simplex type 2 (HSV-2) intravaginal infection in a murine model has been investigated.

Application

N-Lauroylsarcosine may be used as a permeation enhancer in the transdermal drug delivery formulations since it increases the fluidity of stratum corneum lipid structure of the skin†

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
BCCG8849
BCCG5961
BCCG6616
BCCG6241
BCCG0145

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문서 라이브러리 방문

Yoshiaki Furukawa et al.
The Journal of biological chemistry, 285(29), 22221-22231 (2010-04-21)
More than 100 different mutations in Cu,Zn-superoxide dismutase (SOD1) are linked to a familial form of amyotrophic lateral sclerosis (fALS). Pathogenic mutations facilitate fibrillar aggregation of SOD1, upon which significant structural changes of SOD1 have been assumed; in general, however
Yeu-Chun Kim et al.
International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)
To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery
Kunie Ando et al.
The American journal of pathology, 178(2), 803-816 (2011-02-02)
Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau. Because murine tau might interfere with the toxic effects of human mutant tau, we generated a
Yoshiaki Furukawa et al.
The Journal of biological chemistry, 286(21), 18664-18672 (2011-04-02)
The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS) patients. Here
S Roy et al.
Antimicrobial agents and chemotherapy, 45(6), 1671-1681 (2001-05-17)
The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS
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