89458
Aphidicolin
analytical standard
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H34O4
CAS 번호:
Molecular Weight:
338.48
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
MDL number:
제품 이름
Aphidicolin, analytical standard
Quality Level
InChI key
NOFOAYPPHIUXJR-APNQCZIXSA-N
SMILES string
C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]3C[C@@H]4C[C@]23CC[C@]4(O)CO
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
grade
analytical standard
assay
≥95% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
storage temp.
2-8°C
Application
Aphidicolin may be used as a reference standard in the determination of the analyte in plasma samples using gas chromatography coupled with mass spectrometry (GC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Aphidicolin is a diterpenoid metabolite of the fungi, Cephalosporium aphidicola and Phoma betae. It is known to be an antiviral drug and inhibits the incorporation of thymidine into DNA of cultured human embryonic lung cells.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Chemistry of Fungi (2008)
Aphidicolin: A specific inhibitor of DNA polymerases in the cytosol of rat liver.
Ohashi M, et al.
Biochemical and Biophysical Research Communications, 82(4), 1084-1090 (1978)
A gas chromatographic mass spectrometric assay for the determination of aphidicolin in plasma of cancer patients.
Journal of Pharmaceutical Sciences, 78(5), 399-401 (1989)
Devin Sok et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), 17624-17629 (2014-11-26)
Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine design and immunotherapy because of their great neutralization breadth and potency. However, methods of isolating bnAbs against this site have been limited by the
Julian H Elliott et al.
PLoS pathogens, 10(10), e1004473-e1004473 (2014-11-14)
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining HIV latency and histone deacetylase inhibitors (HDACi) may reverse latency by activating HIV
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